Assessment of liver allograft function by hyaluronic acid and endothelin levels

The Journal of Surgical Research
T SuehiroC M Miller

Abstract

Sinusoidal endothelial cells are considered the primary site of preservation-reperfusion injury occurring during cold storage and reperfusion. Hyaluronic acid (HA) and endothelin-1 (ET) are markers of endothelial cell integrity. The aim of this study was to evaluate the possible correlation between these markers and early graft function following liver transplantation. Blood samples were collected from 85 adult orthotopic liver transplant recipients at the following time points: before surgery, just before reperfusion, first and last 20 cc of caval effluent, 30, 60, and 120 min after reperfusion, and on postoperative day (POD) 1. Levels of both HA and ET were measured by sandwich enzyme-binding assay. HA uptake was also defined for every sample as the ratio of the actual measurement to the value obtained just before reperfusion. Patients with severe liver disease displayed significantly higher pretransplant HA and ET levels compared with those of less advanced illness. Poor early graft function (PEGF) was defined as peak enzyme levels on the first three PODs higher than 2500 U/L and prothrombin time longer than 16 s on POD 2. Patients with PEGF (n = 9) showed significantly lower HA uptake than patients with good graft function ...Continue Reading

References

Nov 1, 1992·The American Review of Respiratory Disease·R K Reed, U B Laurent
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M UchiharaF Marumo
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T IkedaK Sugimachi
May 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·K ChichibuM M Yokoyama
Mar 1, 1989·Transplantation·D H AdamsJ M Neuberger
Mar 31, 1989·Journal of Immunological Methods·N SuzukiM Fujino
Sep 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C Caldwell-KenkelJ J Lemasters
Jun 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·F M RosmalenT J Benraad
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NybergL Lööf
Oct 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·A Engström-LaurentT C Laurent
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Engström-LaurentT Schröder
Jan 1, 1984·Clinical and Experimental Pharmacology & Physiology·J R FraserU G Laurent
Mar 1, 1983·Experimental Cell Research·S ErikssonB Smedsrød
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H ShimizuR E Falk
Sep 1, 1993·Journal of Hepatology·S MøllerJ H Henriksen

❮ Previous
Next ❯

Citations

May 7, 2014·Journal of Hepatology·Cornelia J VerhoevenLuc J W van der Laan
Apr 29, 2004·Transplantation·Ramon MartíRosa M Segura
May 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M Kukan, P S Haddad
Jan 28, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Johan Friso LockMartin Stockmann
Feb 9, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Robert Hayden BroomheadSusan Mallett
Apr 6, 2004·Critical Care Medicine·Richard A Wiklund

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.