Assessment of local blood flow with laser Doppler flowmetry in irradiated mandibular and frontal bone, an experiment in Göttingen minipigs

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Lucas PoortPeter Kessler

Abstract

The aim of this study was to investigate local blood flow changes in the mandibular bone compared to the os frontale after irradiation in various doses. This study used an animal experiment with 16 female Göttingen minipigs. Three groups of four animals were irradiated with equivalent doses of 25, 50 or 70 Gray on the mandible and os frontale and four animals served as control. Three months after irradiation laser Doppler flowmetry (LDF) was used to record local blood flow on the left mandible and in the irradiated area on the os frontale. At 6 months measurements were repeated. Descriptive and univariate analyses were conducted and p-values lower than 0.05 were considered statistically significant. Local blood flow measurements in the mandible were significantly higher compared to the os frontale. In the os frontale and mandible there was no significant change in the measurements with increasing irradiation dose. We found a non-significant decrease in LDF values with an increase in radiation dose in the mandible and non-significant changes in the os frontale at 3 and 6 months. We consider this to represent the process of on-going fibrosis affecting the local blood flow in the mandible.

References

Jan 1, 1989·Journal of Orthopaedic Trauma·M F SwiontkowskiR B Shack
Oct 1, 1987·Oral Surgery, Oral Medicine, and Oral Pathology·R E Marx, R P Johnson
Apr 1, 1996·Journal of Glaucoma·G MichelsonM J Groh
Sep 25, 1999·Seminars in Cell & Developmental Biology·D M GardinerS Roy
May 25, 2002·Cancer Treatment Reviews·Barbara A Jereczek-Fossa, Roberto Orecchia
Feb 8, 2005·International Journal of Oral and Maxillofacial Surgery·C KlugR Ewers
Jan 10, 2006·Current Problems in Diagnostic Radiology·James Teh
Jun 20, 2008·The British Journal of Oral & Maxillofacial Surgery·Andrew Lyons, Naseem Ghazali
Sep 17, 2010·Oral Oncology·Adam S JacobsonMark L Urken
Mar 24, 2011·Experimental Biology and Medicine·Juna Lee, Chulso Moon
Jun 11, 2011·International Journal of Radiation Oncology, Biology, Physics·Peter PaximadisHarold Kim
Dec 24, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·V E M MulB G Baumert
May 18, 2012·Journal of Dental Research·J XuS L Wang
Jun 22, 2012·International Journal of Radiation Oncology, Biology, Physics·Marjolein J BoomsmaJohannes A Langendijk

❮ Previous
Next ❯

Citations

Mar 21, 2017·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Lucas J PoortPeter A W H Kessler
Mar 25, 2017·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Lucas J PoortPeter A W H Kessler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Lucas PoortPeter Kessler
Journal of the New Zealand Society of Periodontology
N Chandler
© 2022 Meta ULC. All rights reserved