Assessment of lymphatic impairment and interstitial protein accumulation in patients with breast cancer treatment-related lymphedema using CEST MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Manus J DonahueSeth A Smith

Abstract

Lymphatic impairment is known to reduce quality of life in some of the most crippling diseases of the 21st century, including obesity, lymphedema, and cancer. However, the lymphatics are not nearly as well-understood as other bodily systems, largely owing to a lack of sensitive imaging technologies that can be applied using standard clinical equipment. Here, proton exchange-weighted MRI is translated to the lymphatics in patients with breast cancer treatment-related lymphedema (BCRL). Healthy volunteers (N = 8) and BCRL patients (N = 7) were scanned at 3 Tesla using customized structural MRI and amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI in sequence with the hypothesis that APT effects would be elevated in lymphedematous tissue. APT contrast, lymphedema stage, symptomatology, and histology information were evaluated. No significant difference between proton-weighted APT contrast in the right and left arms of healthy controls was observed. An increase in APT contrast in the affected arms of patients was found (P = 0.025; Cohen's d = 2.4), and variability among patients was consistent with documented damage to lymphatics as quantified by lymphedema stage. APT CEST MRI may have relevance for evalu...Continue Reading

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Citations

Aug 27, 2016·EJNMMI Physics·B WuG Delso
Mar 1, 2017·Journal of Magnetic Resonance Imaging : JMRI·Rachelle CrescenziManus J Donahue
Jun 13, 2018·Radiology·Benjamin King Hong LawJing Yuan
Dec 19, 2018·Lymphatic Research and Biology·Rebecca M GarzaDavid W Chang
Aug 10, 2017·Journal of Magnetic Resonance Imaging : JMRI·Kyle M JonesMark D Pagel
Oct 22, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rachelle CrescenziManus J Donahue
Feb 24, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jiadi XuPeter C M van Zijl
Jun 2, 2020·Frontiers in Medicine·Apekshya ChhetriJoseph V Rispoli
Sep 7, 2020·Advanced Drug Delivery Reviews·Anna K Polomska, Steven T Proulx
May 1, 2021·Diagnostics·Rima HajjoAlexander Tropsha
Oct 4, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christian T McHughRosa T Branca
Nov 30, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pei HanDebiao Li

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