PMID: 8938814Oct 1, 1996Paper

Assessment of lymphocyte subsets and neutrophil leukocyte function in chronic psychiatric patients on long-term drug therapy

Progress in Neuro-psychopharmacology & Biological Psychiatry
M CosentinoG M Frigo

Abstract

1. Lymphocyte subsets and neutrophil function were studied in chronic psychiatric patients on long-term multiple drug therapy, and the correlation with disease and drug treatments was also investigated. 2. Patients showed decreased CD4+ percentage, CD4+/CD8+ ratio, B lymphocyte percentage, increased absolute and percentage NK, and impaired neutrophil chemotaxis, phagocytosis, and oxidative metabolism. Correlations were found between: patient status and lower CD4+ percentage, CD4+/CD8+ ratio, neutrophil chemotaxis, phagocytosis, and oxidative metabolism; schizophrenia and higher absolute and percentage NK, and neutrophil random migration; benzodiazepines and higher CD8+ absolute number and lower NBT reduction frequency; carbamazepine and higher NK percentage, neutrophil chemotaxis, phagocytosis, stimulated O2-production, and lower microbicidal activity. 3. The present study provides direct evidence for the existence of immunologic abnormalities in a population of chronic psychiatric patients on long-term drug therapy. Although a possible role by other factors could not be excluded, such abnormalities are strongly associated with chronic administration of benzodiazepines and carbamazepine. Further investigations are warranted to ...Continue Reading

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Citations

Aug 15, 1998·Annals of the New York Academy of Sciences·E CaldiroliG M Frigo
Jun 26, 2009·Psychoneuroendocrinology·M P ViverosL M Garcia-Segura
Feb 25, 2009·Annals of the New York Academy of Sciences·M De la FuenteM P Viveros
Jun 22, 2006·Neurotoxicology·G Jean HarrySusan H Brunssen
Feb 14, 2006·Trends in Molecular Medicine·Jonathan KipnisMichal Schwartz
Aug 9, 2017·Early Intervention in Psychiatry·Clemente Garcia-RizoMiquel Bernardo
Aug 1, 1997·Immunopharmacology and Immunotoxicology·E CaldiroliG M Frigo
Apr 28, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Gerald StoberPeter Riederer

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