Assessment of mammographic density before and after first full-term pregnancy

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Christian R LoehbergPeter A Fasching

Abstract

Mammographic density (MD) has consistently been found as one of the strongest breast cancer risk factors. In our study, both qualitative and quantitative density measurements were performed in a hospital-based group of premenopausal women before and after first full-term pregnancy providing an opportunity for direct evaluation of the effects of one pregnancy on MD. Mammograms were obtained from 23 women before and after first full-term pregnancy and from 28 nulliparous controls. MD was determined by a standard qualitative assessment method using the Breast Imaging Reporting and Data System, and a quantitative computer-based threshold method (0-100%). The mean age at mammography before and after pregnancy was 31 and 34 years, respectively, with a mean difference of 40 months between mammographies. The quantitative density assessment showed a significant reduction in relative MD after pregnancy of 12 percentage points (8.6-15.4), compared with 3.1 (0.0-6.2) in the nulliparous control group (P<0.001). A reduction in MD of more than 10% was seen in 52% of the patients, compared with 18% of the controls. The qualitative density assessment confirmed a reduction in MD after pregnancy by one Breast Imaging Reporting and Data System cat...Continue Reading

Associated Clinical Trials

References

Jun 1, 1978·AJR. American Journal of Roentgenology·S HainlineW Shingleton
Jan 1, 1985·The British Journal of Radiology·J S GroveM P Mi
Jan 1, 1982·Breast Cancer Research and Treatment·Jose RussoIrma H Russo
Jan 1, 1983·American Journal of Epidemiology·S P HelmrichM Levy
Mar 1, 1982·American Journal of Epidemiology·J BrissonF Merletti
Mar 1, 1980·Radiology·V L ErnsterR J Schweitzer
Nov 1, 1995·Journal of the National Cancer Institute·Celia ByrneR Haile
Oct 15, 1995·American Journal of Epidemiology·S A BartowM C Pike
Aug 19, 1999·Journal of the National Cancer Institute·Norman BoydD L Tritchler
Apr 25, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Norman BoydA B Miller
Nov 7, 2000·Cancer Causes & Control : CCC·Jenny Chang-ClaudeH Becher
Feb 15, 2001·JAMA : the Journal of the American Medical Association·C M RutterS Taplin
Mar 15, 2001·Cancer Causes & Control : CCC·Celia ByrneR Hoover
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·L SivaramanB W O'Malley
Jan 2, 2003·Journal of the National Cancer Institute·Gail A GreendaleGiske Ursin
Jun 24, 2003·Breast Cancer Research : BCR·Melanie R Ginger, Jeffrey M Rosen
Apr 22, 2004·Journal of the National Cancer Institute·Jack CuzickStephen W Duffy
Sep 8, 2004·Maturitas·Ruth M L Warren
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Jose RussoIrma H Russo
Oct 4, 2005·The Lancet Oncology·Norman BoydAndrew D Paterson
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gertraud MaskarinecLaurence N Kolonel
Apr 20, 2006·Journal of the National Cancer Institute·Nadine AndrieuIBCCS Collaborators Group
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Valerie A McCormack, Isabel dos Santos Silva
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Norman BoydSalomon Minkin
Jan 19, 2007·The New England Journal of Medicine·Norman BoydMartin J Yaffe
Mar 8, 2007·Journal of the National Cancer Institute·Karla KerlikowskeNational Institutes of Health Breast Cancer Surveillance Consortium
Jan 15, 2008·Breast Cancer Research : BCR·Celine M VachonV Shane Pankratz
Jan 18, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jose RussoIrma H Russo
Jul 5, 2008·Breast Cancer Research : BCR·Martin J Yaffe
Jul 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sarah J LordGiske Ursin
Feb 7, 2009·Biometrical Journal. Biometrische Zeitschrift·Lothar HäberleOlaf Gefeller
Nov 17, 2009·American Journal of Epidemiology·Jennifer StoneJack Cuzick

Citations

Aug 13, 2013·Cancer Causes & Control : CCC·Joanne F DorganNola M Hylton
Aug 23, 2017·Breast Cancer Research and Treatment·Carolin C HackUwe G Pöhls
Oct 2, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Claudia RauhChristian M Bayer
Mar 22, 2020·Scientific Reports·Marius WunderlePeter A Fasching

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.