Assessment of markers of thrombin generation in patients with acute myocardial infarction complicated by ventricular fibrillation.

Clinical Cardiology
Elif ElmasMartin Borggrefe

Abstract

In most cases, sudden cardiac death is triggered by ischemia-related ventricular tachyarrhythmias and accounts for 50% of deaths from cardiovascular disease in developed countries. Chronic elevation of indicators of coagulation activation has been found in patients with coronary heart disease, but a role of coagulation activation as a potential risk factor for ventricular fibrillation (VF) during acute myocardial infarction (MI) has not been investigated. We enrolled 50 patients with a history of MI, of whom 26 presented with VF in the acute phase of myocardial ischemia; 24 patients had an acute MI without ventricular tachyarrhythmias. Levels of thrombin-antithrombin complexes (TAT), prothrombin fragment F1 + 2 (F1 + 2), fibrinopeptide A (FPA), plasmin-antiplasmin complexes (PAP), protein C, antithrombin, activated partial thromboplastin time (aPTT), thromboplastin time, D-Dimer, fibrinogen, and high-sensitivity C-reactive protein (hs-CRP) were measured in plasma samples of all patients. Blood collection was obtained sequentially in two separate settings. Patients were studied at a median of 351 days after the acute coronary event. Higher levels of TAT complexes (13.4 +/- 22.2 vs. 3.03 +/- 4.3 microg/l; p = 0.02), FPA (79.7 +/-...Continue Reading

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Citations

Jun 20, 2008·British Journal of Haematology·J J van VeenM Makris
Aug 27, 2013·International Journal of Cardiology·Michael BehnesElif Elmas
Jul 20, 2014·International Journal of Cardiology·Viktor Culić
Aug 26, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Johanne SilvainUNKNOWN ATOLL Investigators

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