Assessment of mechanical properties of porcine aortas under physiological loading conditions using vascular elastography

Journal of the Mechanical Behavior of Biomedical Materials
Edgar J S MascarenhasRichard G P Lopata

Abstract

Non-invasive assessment of the elastic properties of the arterial wall is often performed with ultrasound (US) imaging. The purpose of this study is to estimate mechanical properties of the vascular wall using in vitro inflation testing on biological tissue and two-dimensional (2-D) US elastography, and investigate the performance of the proposed methodology for physiological conditions. An inflation experiment was performed on 12 porcine aortas for (a) a large pressure range (0-140mmHg); and (b) physiological pressures (70-130mmHg) to mimic in vivo hemodynamic conditions. Two-dimensional radiofrequency (RF) data were acquired for one longitudinal and two transverse cross-sections for both experiments, and were analyzed to obtain the geometry and diameter-time behavior. The shear modulus (G) was estimated from these data for each pressure range applied. In addition, an incremental study based on the static data was performed to (1) investigate the changes in G for increasing mean arterial pressure (MAP) for a certain pressure difference (30, 40, 50 and 60mmHg); (2) compare the results with those from the dynamic experiment, for the same pressure range. The resulting stress-strain curves and shear moduli G (94±16kPa) for the sta...Continue Reading

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Citations

Dec 23, 2020·Ultrasound in Medicine & Biology·Niels J PettersonRichard G P Lopata
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Emiel M J van DisseldorpRichard G P Lopata
Apr 18, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Niels PettersonRichard Lopata

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