PMID: 8947318Nov 1, 1996Paper

Assessment of medication compliance in alcoholics through UV light detection of a riboflavin tracer

Alcoholism, Clinical and Experimental Research
F K Del BocaP F Korner

Abstract

Compliance with the medication regimen in treatment trials for alcoholism appears to be a key determinant of treatment outcome. However, there is no consensus as to the best method to assess medication compliance. This study examines the feasibility of using ultraviolet light detection of a urinary riboflavin tracer to determine compliance with medication therapy. Six sets of urine specimens (with n ranging from 15 to 38) were rated independently by two judges. Test-retest reliability was high: 90 and 95% agreement for two judges. Inter-rater reliability ranged from 73 to 95% agreement between judges (mean = 88%), with correspondence kappa values ranging from 0.46 to 0.85 (mean = 0.69). Diaries, capsule counts, and spectrofluorimetric data were used to validate judges' ratings in four trials, including one in which subjects were alcohol-dependent participants in one of three pharmacotherapy trials. Rating accuracy was influenced by dosage, time interval between ingestion and urine collection, and previous dosing. Overall, ratings tended to be accurate, with incorrect judgments limited to specimens with low concentrations of urinary riboflavin. The results indicate that ultraviolet light detection of urinary riboflavin is a usef...Continue Reading

References

Mar 1, 1978·Clinical Pharmacology and Therapeutics·H P Roth, H S Caron
Nov 1, 1992·Archives of General Psychiatry·T R KostenR S Schottenfeld
Aug 1, 1989·Clinical Pharmacology and Therapeutics·P RuddG Marshall
Jun 9, 1989·JAMA : the Journal of the American Medical Association·J A CramerV L Ouellette
Feb 1, 1989·Journal of Behavioral Medicine·I E BabikerM G Gillett
Aug 1, 1989·Clinical Pharmacology and Therapeutics·T PullarM Feely
Jan 1, 1988·Journal of Substance Abuse·J T SullivanE M Sellers
Jan 1, 1988·European Journal of Clinical Pharmacology·N D PennH Tindall
Sep 19, 1986·JAMA : the Journal of the American Medical Association·R K FullerI Lowenstam
Sep 1, 1985·Journal of Behavioral Medicine·P M DubbertM Lake
Mar 1, 1970·Clinical Pharmacology and Therapeutics·H P RothB P Hsi
Jan 1, 1983·Journal of Chronic Diseases·R FullerS Long
Dec 1, 1984·Controlled Clinical Trials·L M YoungJ P van Eeckhout
Oct 1, 1984·Journal of Consulting and Clinical Psychology·P A ClussG Friday
Dec 1, 1984·Controlled Clinical Trials·L Gordis
Dec 1, 1982·Journal of Consulting and Clinical Psychology·L H Epstein, P A Cluss
Jun 1, 1995·Drug and Alcohol Dependence·H R KranzlerV Klinghoffer
Mar 1, 1995·The American Journal of Psychiatry·H R KranzlerN Liebowitz
Sep 1, 1994·Archives of General Psychiatry·H R KranzlerM J Bohn
May 1, 1993·Journal of Substance Abuse Treatment·H R KranzlerJ Brown

❮ Previous
Next ❯

Citations

Jun 17, 2005·Journal of Behavioral Medicine·Joy M SchmitzMarc E Mooney
Apr 24, 2001·Addictive Behaviors·J M SchmitzJ Grabowski
May 1, 1997·Addictive Behaviors·H R KranzlerM J Bohn
Jun 22, 2001·Drug and Alcohol Dependence·J M SchmitzJ Grabowski
Sep 18, 2002·Drug and Alcohol Dependence·Charla Nich, Kathleen M Carroll
Feb 26, 1998·Drug and Alcohol Dependence·V Modesto-LoweH R Kranzler
Feb 14, 2007·Experimental and Clinical Psychopharmacology·Damaris J RohsenowGary B Kaplan
Jun 16, 2010·Experimental and Clinical Psychopharmacology·Joy M SchmitzF Gerard Moeller
Sep 29, 2011·Experimental and Clinical Psychopharmacology·Rebecca L Ashare, Sherry A McKee
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lara A RayKaren Miotto
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kent E HutchisonRobert Swift
Oct 21, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Bethany K BrackenScott E Lukas
Mar 29, 2001·Journal of Clinical Psychopharmacology·H M PettinatiA Cnaan
Dec 1, 1996·Alcoholism, Clinical and Experimental Research·H R KranzlerT F Babor
Feb 1, 1997·Alcoholism, Clinical and Experimental Research·T I MuellerP R Recupero
Sep 2, 1999·Alcoholism, Clinical and Experimental Research·P M MontiD B Abrams
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·D J RohsenowC A Eaton
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·H M PettinatiA Cnaan
Aug 11, 2012·Substance Abuse : Research and Treatment·David M PenetarScott E Lukas
Apr 12, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sherry A McKeeSabrina Coppola
Jun 21, 2014·The American Journal of Drug and Alcohol Abuse·Lara A RayEdythe D London
Dec 25, 2012·Pharmacology, Biochemistry, and Behavior·Lorenzo LeggioGeorge A Kenna
Aug 4, 2004·Journal of Gerontological Nursing·Elizabeth A SchlenkSandra Engberg
Dec 9, 2008·Drug and Alcohol Dependence·Marc E MooneyJohn Grabowski
Oct 1, 2008·Pharmacology, Biochemistry, and Behavior·Lara A RayKent E Hutchison
Jan 1, 2008·Drug and Alcohol Dependence·Joy M SchmitzJohn Grabowski
Sep 11, 2003·Alcoholism, Clinical and Experimental Research·Richard FeinnHenry R Kranzler
Dec 13, 2006·Addiction·Keron FletcherJonathan Chick
Mar 22, 2007·Alcoholism, Clinical and Experimental Research·Alicia M BarosRaymond F Anton
Jan 20, 2011·Alcoholism, Clinical and Experimental Research·David M PenetarScott E Lukas
Sep 8, 2012·Pharmacology, Biochemistry, and Behavior·James R AshenhurstLara A Ray
May 3, 2015·Pharmacology, Biochemistry, and Behavior·Daniel J O RocheLara A Ray

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