Assessment of morphological and functional changes in organs of rats after intramuscular introduction of iron nanoparticles and their agglomerates

BioMed Research International
Elena SizovaValentina Polyakova

Abstract

The research was performed on male Wistar rats based on assumptions that new microelement preparations containing metal nanoparticles and their agglomerates had potential. Morphological and functional changes in tissues in the injection site and dynamics of chemical element metabolism (25 indicators) in body were assessed after repeated intramuscular injections (total, 7) with preparation containing agglomerate of iron nanoparticles. As a result, iron depot was formed in myosymplasts of injection sites. The quantity of muscle fibers having positive Perls' stain increased with increasing number of injections. However, the concentration of the most chemical elements and iron significantly decreased in the whole skeletal muscle system (injection sites are not included). Consequently, it increased up to the control level after the sixth and the seventh injections. Among the studied organs (liver, kidneys, and spleen), Caspase-3 expression was revealed only in spleen. The expression had a direct dependence on the number of injections. Processes of iron elimination from preparation containing nanoparticles and their agglomerates had different intensity.

References

Jan 5, 2002·Physiological Reviews·Wulf Dröge
Jan 13, 2004·Biological Trace Element Research·Erdal KurtogluLevent Undar
Dec 29, 2004·Life Sciences·Jinsong ZhangLide Zhang
Feb 22, 2007·The Journal of Nutrition·Fabian RohnerMichael B Zimmermann
Sep 14, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Bernd DresowPeter Nielsen
Nov 26, 2008·Bulletin of Experimental Biology and Medicine·A D Durnev
Nov 26, 2008·Small·Manuela Semmler-BehnkeWolfgang Brandau
Oct 7, 2011·International Journal of Nanomedicine·Xiao-Dong ZhangFei-Yue Fan
Nov 30, 2011·Annals of Nutrition & Metabolism·Richard F Hurrell
Apr 30, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mohamad F AslamDora I A Pereira

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Citations

Feb 18, 2017·Environmental Science and Pollution Research International·Elena SheidaSvetlana Notova
Apr 20, 2019·Environmental Science and Pollution Research International·Elena SizovaXenia Nechitailo

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BETA
atomic force microscopy

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MS Excel

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