Abstract
In order to provide a comprehensive estimate of the health risks for OSA patients, we analyzed multiple outcomes and independent predictors of these outcomes in an OSA population evaluated and followed at one sleep center. Cox proportional hazard regression analyses were used in an 8-year follow-up analysis of consecutive OSA patients (N = 1025) and non-apneic snorers (apnea-hypopnea index < 5, N = 494). In our fully adjusted model, independent variables predictive of all-cause mortality, myocardial infarction, cerebral vascular accident, and pulmonary embolus were: older age, male gender, and history of cardiovascular diseases or procedures. In examining subgroups based on age and gender, severe OSA (AHI ≥ 30) was one of the independent predictors of mortality in males and in patients < 50 years old. Severe OSA interacted with maleness, age, and hypertension to predict mortality and myocardial infarction. CPAP use ≥ 4 h/night was associated with lower mortality rates in males and those ≥ 50 years old with severe OSA. Mortality and cardiovascular event outcomes were predicted by demographics and cardiovascular disease history more commonly than by OSA severity. OSA severity was an important predictor of mortality in male and yo...Continue Reading
References
Dec 1, 1988·Chest·M PartinenC Guilleminault
Jul 1, 1988·Chest·J HeT Roth
May 1, 1988·American Journal of Public Health·D L BliwiseW C Dement
Oct 1, 1995·The Journal of Clinical Investigation·V K SomersF M Abboud
Jan 1, 1994·Chest·S P KeenanJ A Fleetham
Mar 8, 2000·The European Respiratory Journal·D VealeP Michard
Feb 24, 2001·Psychiatry and Clinical Neurosciences·R HasegawaK Ozeki
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·E ShaharJ M Samet
Apr 20, 2001·The American Journal of the Medical Sciences·S M Koenig
Aug 24, 2001·Journal of Hypertension·R von KänelJ E Dimsdale
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·T MooeU Wiklund
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·Yüksel PekerJan Carlson
Dec 31, 2002·The European Respiratory Journal·S MartiF Morell
May 4, 2004·European Heart Journal·Olivier MilleronOlivier Dubourg
Mar 2, 2005·The European Respiratory Journal·P LavieP Herer
Mar 23, 2005·Lancet·Jose M MarinAlvar G N Agusti
Jun 11, 2005·Chest·Liam S DohertyWalter T McNicholas
Aug 16, 2005·Chest·Francisco Campos-RodriguezAna Fernandez-Palacin
Oct 26, 2005·Circulation·Silke RyanWalter T McNicholas
Nov 12, 2005·The New England Journal of Medicine·H Klar YaggiVahid Mohsenin
Feb 21, 2007·Journal of Sleep Research·Peretz LavieLena Lavie
Mar 16, 2007·Chest·Roland von KänelJoel E Dimsdale
Aug 4, 2007·American Journal of Respiratory and Critical Care Medicine·Nikolaus J BuchnerLars C Rump
Aug 22, 2008·Sleep·Terry YoungK Mae Hla
Feb 24, 2009·The American Journal of Cardiology·Noriaki Takama, Masahiko Kurabayashi
Aug 19, 2009·PLoS Medicine·Naresh M PunjabiJonathan M Samet
Mar 27, 2010·American Journal of Respiratory and Critical Care Medicine·Susan RedlineNaresh M Punjabi
Jun 19, 2010·The New England Journal of Medicine·Robert W YehAlan S Go
Jul 14, 2010·Circulation·Daniel J GottliebEyal Shahar
Oct 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Stuart F QuanClete A Kushida
Citations
Aug 13, 2013·PloS One·Xiahui GeXuejun Guo
Feb 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Sanjay R Patel
Feb 3, 2016·Chinese Medical Journal·Filipa Ramalho FernandesAntonio M Esquinas
Oct 31, 2012·European Journal of Clinical Investigation·Oreste MarroneGiuseppe Insalaco
May 21, 2013·Atherosclerosis·Jia-Yi DongLi-Qiang Qin
Jan 24, 2014·International Journal of Cardiology·Min LiZhen-Yu Tang
Dec 19, 2017·Sleep & Breathing = Schlaf & Atmung·Zesheng WuZhidong Guo
Oct 31, 2014·Stroke; a Journal of Cerebral Circulation·James F MeschiaUNKNOWN Council on Hypertension
Apr 30, 2016·American Journal of Respiratory and Critical Care Medicine·Susmita ChowdhuriUNKNOWN ATS Ad Hoc Committee on Mild Obstructive Sleep Apnea
Jun 10, 2018·Scientific Reports·Yung-An TsouWen-Dien Chang
May 22, 2021·Sleep Medicine Reviews·Pongsakorn Tanayapong, Samuel T Kuna
Nov 20, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nader SalariBehnam Khaledi-Paveh