Assessment of murine startle reactivity, prepulse inhibition, and habituation

Current Protocols in Neuroscience
Mark A Geyer, Stephanie C Dulawa

Abstract

The study of the startle response and its plasticity provides a powerful research paradigm for examining the neural control of behavior. The neural substrates underlying phenomena such as information-processing functions, including sensorimotor gating, affective modulation, and habituation, can be studied using startle plasticity as an operational measure. The mouse is rapidly becoming the most powerful model system for the study of human CNS function and is highly amenable to both genetic and pharmacological study. This unit describes procedures for the assessment of the startle response to acoustic stimuli in mice; methods for assessing prepulse inhibition (PPI) of startle, with treatments including drug administration and genetic manipulation; and methods for testing habituation.

References

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Citations

Jan 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susanne E AhmariH Blair Simpson
Jul 12, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yosefu ArimeIchiro Sora
Mar 11, 2010·Behavioural Pharmacology·Wei-Li ChangNeal R Swerdlow
May 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ali B RodgersTracy L Bale
Mar 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liya YangXinmin Simon Xie
Apr 24, 2017·Psychoneuroendocrinology·Ling-Sha JuAnatoly E Martynyuk
Feb 16, 2016·Depression and Anxiety·Shari A SteinmanH Blair Simpson
Mar 11, 2017·Scientific Reports·Martin WeberKimberly Scearce-Levie
Aug 27, 2005·The Journal of Pharmacology and Experimental Therapeutics·Jacob C OngMark A Geyer
Apr 27, 2013·Anesthesiology·Christoph N SeubertAnatoly E Martynyuk
Feb 17, 2015·Alcoholism, Clinical and Experimental Research·Bahri KaracayDaniel J Bonthius
Feb 28, 2019·Frontiers in Molecular Neuroscience·Qiong ZhangNing-Ning Song
Jul 1, 2020·Frontiers in Behavioral Neuroscience·Madeline M PantoniStephan G Anagnostaras
Aug 5, 2021·Psychopharmacology·Hiba Z VohraJavier González-Maeso

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