Assessment of muscle mass and strength in mice

BoneKEy Reports
Andrea BonettoDavid L Waning

Abstract

Muscle weakness is an important phenotype of many diseases that is linked to impaired locomotion and increased mortality. The force that a muscle can generate is determined predominantly by muscle size, fiber type and the excitation-contraction coupling process. Here we describe methods for the histological assessment of whole muscle to determine fiber cross-sectional area and fiber type, determination of changes in myocyte size using C2C12 cells, in vivo functional tests and measurement of contractility in dissected whole muscles. The extensor digitorum longus and soleus muscles are ideally suited for whole-muscle contractility, and dissection of these muscles is described.

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Citations

Oct 13, 2015·Nature Medicine·David L WaningTheresa A Guise
Aug 31, 2016·Behavioural Brain Research·Marissa Z McMackinGino A Cortopassi
May 13, 2017·Experimental Physiology·Sergio F Martinez-HuenchullanCharmaine S Tam
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Jul 17, 2018·Journal of Cachexia, Sarcopenia and Muscle·Fabrizio PinAndrea Bonetto
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Mar 22, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fabrizio PinAndrea Bonetto
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Oct 16, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Brian A HainDavid L Waning
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