Abstract
The myocardium has the capacity to utilize a variety of metabolic substrates, including long-chain fatty acids, ketone bodies, glucose, lactate, and amino acids. Under most conditions long-chain fatty acids constitute the major myocardial energy source. Imaging of long-chain fatty acids can be accomplished with carbon 11-labeled palmitate (1-11C-palmitate) and positron emission tomography. Imaging can be performed in either static or dynamic modes. In normal subjects accumulation of the tracer is homogeneous throughout the heart. In patients with myocardial infarction, distinct defects in accumulation are seen. In dilated cardiomyopathy, uptake is spatially heterogeneous. Clearance of 1-11C-palmitate in normal myocardium is biexponential and homogeneous throughout the heart. Administration of glucose, or feeding, decreases uptake of the tracer into the early rapid turnover pool and decreases clearance of the tracer from that pool. In normal myocardium atrial pacing increases the rate of clearance; in ischemic myocardium the degree of increased clearance is attenuated. In patients with cardiomyopathy caused by long-chain fatty acid coenzyme A dehydrogenase deficiency, 1-11C-palmitate clearance is diminished compared with total m...Continue Reading
References
Jul 1, 1976·Circulation Research·E S WeissB E Sobel
Jan 1, 1977·Circulation·E S WeissB E Sobel
Jun 1, 1977·Circulation·B E SobelM M Ter-Pogossian
Oct 1, 1977·Circulation Research·C P Rose, C A Goresky
Nov 1, 1989·Progress in Cardiovascular Diseases·P CamiciL H Opie
Jun 1, 1987·The American Journal of Cardiology·J D EisenbergE M Geltman
Apr 1, 1987·International Journal of Cardiology·A S JaffeE M Geltman
Aug 1, 1986·Circulation·M Grover-McKayM E Phelps
Nov 1, 1985·Progress in Cardiovascular Diseases·S R BergmannB E Sobel
Aug 1, 1985·Circulation Research·K A FoxS R Bergmann
Nov 1, 1968·American Heart Journal·L H Opie
Nov 1, 1972·Progress in Cardiovascular Diseases·J R NeelyJ F Oram
Mar 1, 1983·American Heart Journal·H R SchelbertM E Phelps
May 1, 1983·The American Journal of Medicine·E M GeltmanB E Sobel
May 1, 1984·Circulation·B E SobelP A Ludbrook
Feb 1, 1980·Circulation·M M Ter-PogossianB E Sobel
Oct 1, 1981·Circulation·R A LerchB E Sobel
Oct 1, 1982·The American Journal of Medicine·S R BergmannB E Sobel
Mar 15, 1993·The American Journal of Cardiology·D P KellyS R Bergmann
Citations
Jul 11, 2002·Journal of the American College of Cardiology·Víctor G Dávila-RománRobert J Gropler
Jan 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Hugo W A M de JongAdriaan A Lammertsma
Sep 13, 2000·Lipids·E J MurphyS I Rapoport
Oct 2, 2001·Revista española de medicina nuclear·I Peñuelas Sánchez
Apr 1, 2017·Circulation Research·Henry Gewirtz, Vasken Dilsizian
Sep 6, 2005·Amino Acids·R Bergmann, J Pietzsch
Sep 25, 2019·Science Advances·Alejandro Amor-CoarasaJohn W Babich