PMID: 9420693Mar 1, 1994Paper

Assessment of myocardial fatty acid metabolism with 1-11C-palmitate

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
E M Geltman

Abstract

The myocardium has the capacity to utilize a variety of metabolic substrates, including long-chain fatty acids, ketone bodies, glucose, lactate, and amino acids. Under most conditions long-chain fatty acids constitute the major myocardial energy source. Imaging of long-chain fatty acids can be accomplished with carbon 11-labeled palmitate (1-11C-palmitate) and positron emission tomography. Imaging can be performed in either static or dynamic modes. In normal subjects accumulation of the tracer is homogeneous throughout the heart. In patients with myocardial infarction, distinct defects in accumulation are seen. In dilated cardiomyopathy, uptake is spatially heterogeneous. Clearance of 1-11C-palmitate in normal myocardium is biexponential and homogeneous throughout the heart. Administration of glucose, or feeding, decreases uptake of the tracer into the early rapid turnover pool and decreases clearance of the tracer from that pool. In normal myocardium atrial pacing increases the rate of clearance; in ischemic myocardium the degree of increased clearance is attenuated. In patients with cardiomyopathy caused by long-chain fatty acid coenzyme A dehydrogenase deficiency, 1-11C-palmitate clearance is diminished compared with total m...Continue Reading

References

Jun 1, 1987·The American Journal of Cardiology·J D EisenbergE M Geltman
Apr 1, 1987·International Journal of Cardiology·A S JaffeE M Geltman
Nov 1, 1985·Progress in Cardiovascular Diseases·S R BergmannB E Sobel
Nov 1, 1968·American Heart Journal·L H Opie
Nov 1, 1972·Progress in Cardiovascular Diseases·J R NeelyJ F Oram
May 1, 1983·The American Journal of Medicine·E M GeltmanB E Sobel

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Citations

Jul 11, 2002·Journal of the American College of Cardiology·Víctor G Dávila-RománRobert J Gropler
Jan 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Hugo W A M de JongAdriaan A Lammertsma
Oct 2, 2001·Revista española de medicina nuclear·I Peñuelas Sánchez
Sep 6, 2005·Amino Acids·R Bergmann, J Pietzsch
Sep 25, 2019·Science Advances·Alejandro Amor-CoarasaJohn W Babich

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