PMID: 9438506Jan 23, 1998Paper

Assessment of myocardial fibrosis in cardiomyopathic hamsters with gadolinium-DTPA enhanced magnetic resonance imaging

Investigative Radiology
H AsoT Nakagawa

Abstract

The authors investigated whether magnetic resonance (MR) imaging enhanced with gadolinium (Gd)-DTPA would be useful for assessment of myocardial fibrosis in cardiomyopathy. The authors compared MR images of the excised heart after Gd-DTPA injection with histopathologic findings in 33 hamsters with cardiomyopathy of the Bio 14.6 strain and 26 healthy hamsters of various age groups and assessed localization of Gd-14C-DTPA by autoradiography in the myocardium of three hamsters with cardiomyopathy. The mean signal intensity ratios for the entire myocardium in hamsters with cardiomyopathy relative to that in healthy hamsters was significantly higher in a younger age group than in an older age group (1.30+/-0.09 versus 1.03+/-0.08, P < 0.001, respectively). This myocardial enhancement was more obvious in areas containing massive fibrosis in the early and mid stages than in the late stage. Autoradiograms of hamsters with cardiomyopathy showed patchy or linear increases in uptake, corresponding to the areas of myocardial fibrosis. Gadolinium-14C-DTPA radioactivity ratios of myocardial fibrosis to healthy myocardium were significantly higher in the early and mid stages than in the late stage (P < 0.01). Myocardial fibrosis with high cel...Continue Reading

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Citations

Sep 2, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Paul KnaapenFrans C Visser
Jun 22, 2001·AJR. American Journal of Roentgenology·H W GooT H Lim
Mar 21, 2003·AJR. American Journal of Roentgenology·Jan BogaertSteven Dymarkowski
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May 15, 2009·International Journal of Cardiology·J MarmursztejnD Duboc
Feb 4, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Troy J BadgerNassir F Marrouche
Aug 19, 2015·Progress in Nuclear Magnetic Resonance Spectroscopy·Adrianus J BakermansKlaas Nicolay
Jul 24, 2007·International Journal of Cardiology·Paola MelaciniSabino Iliceto
Apr 4, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Makoto OriiTakashi Akasaka
May 17, 2005·Journal of the American College of Cardiology·Jan-Peter SmedemaHarry J G M Crijns
Feb 23, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuki HenTsutomu Yoshikawa
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Apr 22, 2008·Journal of Magnetic Resonance Imaging : JMRI·Young Jin KimJong-Won Ha
Dec 10, 1999·Investigative Radiology·V M Runge

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