PMID: 9556745Apr 29, 1998Paper

Assessment of myocardial perfusion by intermittent harmonic power Doppler using SonoVue, a new ultrasound contrast agent

Investigative Radiology
A BroilletM Schneider

Abstract

The authors evaluated the potential of SonoVue, a new echo contrast agent, for the detection of myocardial perfusion abnormalities using intermittent harmonic power Doppler (IHPD) imaging and different pulse repetition frequencies (PRFs). Experiments were performed in vitro (in a tissue-mimicking phantom) and in vivo (in minipigs) in harmonic power Doppler using an ATL HDI 3000 with second harmonic software. SonoVue was injected intravenously in an auricular vein in bolus (dose range 0.01-0.05 mL/kg) in closed-chest animals or as an infusion (rate = 0.1 mL/kg/minute) in open-chest minipigs with reversible left anterior descending coronary artery (LAD) occlusion. The animals were imaged using IHPD gated on the electrocardiogram at end-systole (pulsing interval at each cardiac cycle). The efficacy of SonoVue was evaluated at six PRFs from 500 to 6000 Hz either qualitatively using a subjective scoring system or quantitatively using a digital image analyzer. SonoVue at a dose of 0.01 mL/kg produced a strong and homogeneous myocardial opacification in IHPD. Higher doses prolonged the duration of the contrast effect. Varying the PRF allowed the discrimination of flow velocities in vitro and the detection of perfusion differences with...Continue Reading

References

Jul 1, 1995·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·H C DittrichY Greener
Jun 1, 1996·Clinical Radiology·J E MacSweeneyJ Arenson

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Citations

Nov 7, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·S LafitteR Roudaut
Jun 14, 2000·AJR. American Journal of Roentgenology·E J HalpernB B Goldberg
Oct 16, 2007·The Journal of Urology·Robert A LindenEthan J Halpern
Sep 19, 2007·Seminars in Ultrasound, CT, and MR·Robert A Linden, Ethan J Halpern
Mar 14, 2013·Journal of Cellular and Molecular Medicine·Claudio MuscariGianandrea Pasquinelli
Oct 26, 2000·Academic Radiology·K W FerraraS A Wickline
Dec 27, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Eran ToledoVictor Mor-Avi
Oct 4, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·J Todd BelcikBrad Roberts
Jan 3, 2006·Journal of the American College of Cardiology·Eran ToledoVictor Mor-Avi
Feb 18, 2010·JACC. Cardiovascular Imaging·Thomas R Porter, Feng Xie
Dec 5, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Raffi BekeredjianHelmut F Kuecherer
Sep 29, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Adam J DixonJohn A Hossack
Mar 5, 2011·Urologia Internationalis·Francesco PintoPierFrancesco Bassi
May 31, 2001·Circulation·F S VillanuevaJ Sklenar
May 24, 2012·Current Opinion in Urology·Chandan R KundavaramEdouard J Trabulsi
Nov 26, 2002·Investigative Radiology·Jean-Michel CorreasGeneviève Berger
Aug 19, 2000·Annals of Medicine·O T Raitakari, D S Celermajer

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