Assessment of myocardial perfusion in coronary artery disease by magnetic resonance: a comparison with positron emission tomography and coronary angiography

Circulation
J SchwitterG K von Schulthess

Abstract

Monitoring contrast medium wash-in kinetics in hyperemic myocardium by magnetic resonance (MR) allows for the detection of stenosed coronary arteries. In this prospective study, the quality of a multislice MR approach with respect to the detection and sizing of compromised myocardium was determined and compared with positron emission tomography (PET) and quantitative coronary angiography. A total of 48 patients and healthy subjects were studied by MR using a multislice hybrid echo-planar pulse sequence for monitoring the myocardial first pass kinetics of gadolinium-diethylenetriamine pentaacetic acid bismethylamide (Omniscan; 0.1 mmol/kg injected at 3 mL/s IV) during hyperemia (dipyridamole 0.56 mg/kg). Signal intensity upslope as a measure of myocardial perfusion was calculated in 32 sectors per heart from pixelwise parametric maps in the subendocardial layer and for full wall thickness. Before coronary angiography, coronary flow reserve (hyperemia induced by dipyridamole 0.56 mg/kg) was determined in corresponding sectors by (13)N-ammonia PET. Receiver-operator characteristic analysis of subendocardial upslope data revealed a sensitivity and specificity of 91% and 94%, respectively, for the detection of coronary artery diseas...Continue Reading

References

Jun 14, 1979·The New England Journal of Medicine·G A Diamond, J S Forrester
Oct 1, 1991·Journal of the American College of Cardiology·W J ManningR R Edelman
Jan 1, 1990·International Journal of Cardiac Imaging·M BüchiH P Krayenbühl
Jun 3, 1988·Science·J A Swets
Jul 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E G WalshG M Pohost
May 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·A C EichenbergerG K von Schulthess
Jun 23, 1994·The New England Journal of Medicine·N G UrenP G Camici
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J SchwitterG C McKinnon
Apr 16, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S DingF H Epstein

❮ Previous
Next ❯

Citations

Feb 12, 2002·Journal of Magnetic Resonance Imaging : JMRI·Dara L KraitchmanDavid A Bluemke
Aug 31, 2002·Journal of Magnetic Resonance Imaging : JMRI·James P EarlsScott D Flamm
Nov 27, 2002·Journal of Magnetic Resonance Imaging : JMRI·Wolfgang Günther SchreiberManfred Thelen
Mar 1, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Frederick H EpsteinAndrew E Arai
May 28, 2010·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·J G J GroothuisA C van Rossum
Oct 2, 2009·Pediatric Radiology·Lorna P BrowneRajesh Krishnamurthy
Mar 6, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Alberto CuocoloAndrea Soricelli
Sep 8, 2004·European Radiology·Jörg BarkhausenKai-Uwe Waltering
Apr 25, 2006·European Radiology·Pierre CroisilleMaythem Saeed
May 4, 2006·European Radiology·Peter HunoldJörg Barkhausen
Jan 9, 2007·European Radiology·Gabriele A KrombachAndreas H Mahnken
Dec 18, 2009·European Radiology·Andreas Max WengHerbert Köstler
Sep 9, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christina DoeschAndreas E May
Oct 31, 2009·The International Journal of Cardiovascular Imaging·F D SantiagoE C de Faria
Feb 2, 2002·Current Atherosclerosis Reports·Wojciech MazurPairoj Rerkpattanapipat
Dec 10, 2003·Current Atherosclerosis Reports·Douglas S JacobyDaniel J Rader
Feb 25, 2005·Current Atherosclerosis Reports·Tarang RaySunil Mankad
Sep 3, 2009·Current Heart Failure Reports·Nuno BettencourtEike Nagel
Mar 8, 2008·Current Treatment Options in Cardiovascular Medicine·Henry D Wu, Raymond Y Kwong
Jun 3, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gabriella VincentiThomas H Schindler
May 18, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Timothy F ChristianMichael Jerosch-Herold
Jul 23, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·K BratisE Nagel
Apr 10, 2009·JACC. Cardiovascular Imaging·Joseph Selvanayagam
Jun 10, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·David C Isbell, Christopher M Kramer
Dec 19, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Juerg Schwitter
Jun 3, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mario PetrettaAlberto Cuocolo
Sep 2, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Amit R PatelChristopher M Kramer
May 28, 2003·The American Journal of Cardiology·Patrick L WhitlowUNKNOWN Eclipse Investigators
Nov 19, 2003·Seminars in Roentgenology·Sandra PujadasCharles B Higgins
Feb 8, 2003·Lancet·Frank E Rademakers
Nov 26, 2002·Journal of the American College of Cardiology·Willemijn L F BedauxAlbert C van Rossum
Dec 12, 2002·Journal of the American College of Cardiology·Emerson C PerinWilliam W O'Neill
Nov 1, 2005·Nature Clinical Practice. Cardiovascular Medicine·Dipan J ShahRaymond J Kim
Aug 26, 2006·Nature Clinical Practice. Cardiovascular Medicine·Santo Dellegrottaglie, Zahi A Fayad
Jun 21, 2002·The New England Journal of Medicine·Jonathan R PantingDudley J Pennell
Mar 15, 2011·European Heart Journal·Juerg Schwitter, Andrew E Arai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.