Assessment of N-terminal pro-B-type natriuretic peptide level in screening for atrial fibrillation in primary health care

PloS One
Faris GhazalFaris Al-Khalili

Abstract

Atrial fibrillation (AF), an important cause of thromboembolic events, is often silent and intermittent, thus presenting a diagnostic challenge. The aim of this study was to assess whether the plasma level of N-terminal pro-brain natriuretic peptide (NT-proBNP) is related to the presence of AF and thereby might be used to facilitate screening programs for AF in primary care. This was a cross sectional screening study. A population of 70-74-year-old individuals registered at a single primary care center in Stockholm were invited to AF screening. Intermittent ECG recording, 30 seconds twice a day using a hand-held device over 2 weeks, was offered to participants without previously known AF. Of the 324 participating persons, 34 patients had already known AF and 16 new cases of AF were detected by screening. Plasma NT-proBNP was measured in patients with previously known AF, newly detected AF, and 53 control participants without AF. The median NT-proBNP was 697 ng/L in patients with previously known AF, 335 ng/L in new cases of AF, and 146 ng/L in patients without AF. After adjustment for several clinical variables and morbidities, the differences of median NT-proBNP levels were statistically significant between cases of previously...Continue Reading

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Citations

Feb 15, 2019·BMJ : British Medical Journal·Mark Lown, Patrick Moran
Oct 1, 2019·Journal of the American Heart Association·Zakaria AlmuwaqqatAlvaro Alonso
Feb 1, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Alireza Sepehri ShamlooArash Arya

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