Assessment of NETest Clinical Utility in a U.S. Registry-Based Study

The Oncologist
Eric LiuLisa Bodei

Abstract

The clinical relevance of molecular biomarkers in oncology management has been recognized in breast and lung cancers. We evaluated a blood-based multigene assay for management of neuroendocrine tumors (NETs) in a real-world study (U.S. registry NCT02270567). Diagnostic accuracy and relationship to clinical disease status in two cohorts (treated and watch-and-wait) were evaluated. Patients with NETs (n = 100) were followed for 6-12 months. Patients' primary tumors were gastroenteropancreatic (68%), lung 20%, and of unknown origin (12%). Characteristics included well-differentiated, low-grade tumors (97%), stage IV disease (96%); treatment with surgery (70%); and drug treatment (56%). NETest was measured at each visit and disease status determined by RECIST. Scores categorized as low (NETest 14%-40%) or high (≥80%) defined disease as stable or progressive. Multivariate analyses determined the strength of the association with progression-free survival (PFS). NETest diagnostic accuracy was 96% and concordant (95%) with image-demonstrable disease. Scores were reproducible (97%) and concordant with clinical status (98%). The NETest was the only feature linked to PFS (odds ratio, 6.1; p < .0001). High NETest correlated with progressiv...Continue Reading

References

Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V E SutliffR T Jensen
Sep 11, 2008·Journal of the National Cancer Institute·Irvin M ModlinElizabeth Snyderwine
Jan 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew H KulkeJames C Yao
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Geoffrey S Ginsburg, Nicole M Kuderer
Apr 25, 2013·World Journal of Gastroenterology : WJG·Jonathan StrosbergKrzysztof J Grzegorzewski
Jan 15, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Matthew H KulkeUNKNOWN National comprehensive cancer network
Sep 9, 2015·The Journal of Clinical Endocrinology and Metabolism·Jarosław B ĆwikłaMark Kidd
Sep 16, 2015·The Lancet Oncology·Kjell ObergJames Goldenring
Jan 12, 2017·The New England Journal of Medicine·Jonathan StrosbergUNKNOWN NETTER-1 Trial Investigators
Apr 10, 2017·Neuroendocrinology·Kjell ObergUNKNOWN Antibes Consensus Conference participants
Aug 15, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nasser HannaGregory Masters
Nov 3, 2017·Journal of Epidemiology·Ayako OkuyamaHiroshi Nishimoto
Nov 18, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Pier Luigi FilossoIrvin Modlin

❮ Previous
Next ❯

Citations

Nov 6, 2018·Nature Reviews. Clinical Oncology·Guido Rindi, Bertram Wiedenmann
Feb 28, 2019·Nature Reviews. Clinical Oncology·Guido Rindi, Bertram Wiedenmann
Feb 13, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Pier Luigi FilossoLisa Bodei
Jun 17, 2020·Frontiers in Oncology·Martine BocchiniMassimiliano Mazza
Feb 28, 2019·Nature Reviews. Clinical Oncology·Lisa BodeiRonald R Salem
Dec 16, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Lisa BodeiIrvin M Modlin
Jan 22, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ÖbergS Paulson
Dec 17, 2019·Advances in Medical Sciences·Anna MalczewskaIrvin M Modlin
Apr 28, 2021·Seminars in Cancer Biology·Grigoris EffraimidisUlla Feldt-Rasmussen
Apr 28, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Wolfgang RollKambiz Rahbar
Aug 15, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I M ModlinK E Öberg
Jan 18, 2019·Neuroendocrinology·Anna MalczewskaJaroslaw Ćwikła
Nov 13, 2021·Experimental and Therapeutic Medicine·Oana Alexandra CiobanuSimona Fica

❮ Previous
Next ❯

Related Concepts

Related Feeds

Body Dysmorphic Disorder

Body dysmorphic disorder is an intense preoccupation with an imagined defect in ones physical appearance. It can be a severely impairing disorder and is common among patients with obsessive-compulsive disorder. Discover the latest research on body dysmorphic disorder here.