Assessment of nonlinear interactions in event-related potentials elicited by stimuli presented at short interstimulus intervals using single-trial data

Journal of Neurophysiology
Charalambos LoizidesGeorgios D Mitsis

Abstract

The recording of brain event-related potentials (ERPs) is a widely used technique to investigate the neural basis of sensory perception and cognitive processing in humans. Due to the low magnitude of ERPs, averaging of several consecutive stimuli is typically employed to enhance the signal to noise ratio (SNR) before subsequent analysis. However, when the temporal interval between two consecutive stimuli is smaller than the latency of the main ERP peaks, i.e., when the stimuli are presented at a fast rate, overlaps between the corresponding ERPs may occur. These overlaps are usually dealt with by assuming that there is a simple additive superposition between the elicited ERPs and consequently performing algebraic waveform subtractions. Here, we test this assumption rigorously by providing a statistical framework that examines the presence of nonlinear additive effects between overlapping ERPs elicited by successive stimuli with short interstimulus intervals (ISIs). The results suggest that there are no nonlinear additive effects due to the time overlap per se but that, for the range of ISIs examined, the second ERP is modulated by the presence of the first stimulus irrespective of whether there is time overlap or not. In other ...Continue Reading

References

Dec 16, 2003·Biological cybernetics·Wilson TruccoloMingzhou Ding
May 16, 2008·Magnetic Resonance Imaging·A Mouraux, G D Iannetti
Jun 6, 2008·Journal of Neurophysiology·G D IannettiA Mouraux
Jun 19, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael C LeeGian Domenico Iannetti

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Citations

Mar 17, 2017·Frontiers in Human Neuroscience·David A BridwellVince D Calhoun
Nov 16, 2019·PLoS Computational Biology·David M AlexanderCees van Leeuwen

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