Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system

Molecular Autism
Hirokazu KumazakiMasaru Mimura

Abstract

Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 ± 0.28 vs 1.57 ± 0.15; p < 0.001) and allyl caproate ( 3.30 ± 0.23 vs 1.17 ± 0.08; p < 0.001). We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understandi...Continue Reading

References

Sep 1, 1989·Journal of Autism and Developmental Disorders·H KuritaK Katsuno
Mar 1, 1980·Journal of Autism and Developmental Disorders·E SchoplerK Daly
Jul 1, 1996·Perception & Psychophysics·P Dalton, C J Wysocki
Jun 1, 1997·Archives of Otolaryngology--head & Neck Surgery·T M Davidson, C Murphy
Jul 1, 1997·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·M A Kientz, W Dunn
Aug 8, 2002·Journal of the International Neuropsychological Society : JINS·Christina ObergLars Bäckman
Jan 10, 2003·Psychiatry and Clinical Neurosciences·Hisateru TachimoriHiroshi Kurita
Jan 31, 2003·The Journal of Neuropsychiatry and Clinical Neurosciences·Yusuke SuzukiDeclan G M Murphy
Apr 5, 2003·Journal of Cognitive Neuroscience·Anna BonnelAnne-Marie Bonnel
Nov 8, 2003·Journal of the Air & Waste Management Association·James R KastnerRon McClendon
Jan 13, 2004·Journal of Autism and Developmental Disorders·Sally J RogersElizabeth Wehner
Nov 30, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sally J Rogers, Sally Ozonoff
Apr 15, 2006·Autism : the International Journal of Research and Practice·Miriam LissMarcel Kinsbourne
Oct 4, 2006·Journal of Autism and Developmental Disorders·Susan R LeekamJudith Gould
Apr 18, 2007·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Scott D Tomchek, Winnie Dunn
Jun 19, 2007·Biological Psychiatry·Loisa BennettoSusan L Hyman
Jan 8, 2008·Psychoneuroendocrinology·Janice K Kiecolt-GlaserRonald Glaser
May 31, 2008·Journal of Autism and Developmental Disorders·Ayelet Ben-SassonEynat Gal
Jul 25, 2008·Biological Psychiatry·Emma AshwinSimon Baron-Cohen
Oct 29, 2008·Neuropsychology Review·Lauren KenworthyGregory L Wallace
Mar 14, 2009·Journal of Autism and Developmental Disorders·Lisa D WigginsLauren B Adamson
Aug 1, 2009·Journal of Autism and Developmental Disorders·Alison E LaneManya T Angley
May 4, 2010·Journal of Clinical and Experimental Neuropsychology·Margareta HednerThomas Hummel
Aug 11, 2010·Journal of Autism and Developmental Disorders·Michal HrdlickaIva Dudova
Sep 21, 2010·Journal of Autism and Developmental Disorders·Tamara MayBruce J Tonge
Jan 14, 2011·European Annals of Otorhinolaryngology, Head and Neck Diseases·Y SoudryP Bonfils
Apr 30, 2011·European Child & Adolescent Psychiatry·Iva DudovaMichal Hrdlicka
Jul 7, 2011·Journal of Autism and Developmental Disorders·T Tavassoli, S Baron-Cohen
Dec 20, 2011·Schizophrenia Research·Dolores MalaspinaDaniel Antonius
Mar 27, 2012·Chemosensory Perception·Bettina M Pause
Feb 19, 2013·Biological Psychiatry·Valentina ParmaUmberto Castiello
May 10, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer H Foss-FeigCarissa J Cascio
Jan 9, 2014·Neuropsychiatric Disease and Treatment·Iva Dudova, Michal Hrdlicka
Jun 15, 2014·Journal of the Academy of Nutrition and Dietetics·Kristie L HubbardLinda G Bandini
Apr 4, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Nadia Aguillon-HernandezBoriana Atanasova
Jan 1, 2014·Molecular Autism·Chris AshwinSimon Baron-Cohen
Jul 7, 2015·Current Biology : CB·Liron RozenkrantzNoam Sobel

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Citations

Feb 23, 2018·Journal of Autism and Developmental Disorders·Hirokazu KumazakiYoshio Minabe
May 30, 2017·Frontiers in Psychology·Maria LarssonStefan Wiens
Aug 6, 2018·Journal of Autism and Developmental Disorders·Hirokazu KumazakiMitsuru Kikuchi
May 13, 2019·Journal of Autism and Developmental Disorders·Hirokazu KumazakiMitsuru Kikuchi
Jul 27, 2017·Frontiers in Behavioral Neuroscience·Mariko UmemuraYuji Takahashi
Jul 27, 2017·Journal of Autism and Developmental Disorders·Filippo MuratoriAntonio Narzisi
Dec 14, 2018·Autism : the International Journal of Research and Practice·Anne-Claude LuisierMoustafa Bensafi
Oct 31, 2020·Disability and Rehabilitation. Assistive Technology·Christos-Marios PontikasAspasia Serdari

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Fragrance Jet for
Fragrance Jet
Statistical Package for the Social Sciences ( SPSS

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