Assessment of parasitological findings in heartworm-infected beagles treated with Advantage Multi® for dogs (10% imidacloprid + 2.5% moxidectin) and doxycycline

Parasites & Vectors
Molly D SavadelisAndrew R Moorhead

Abstract

Anecdotal reports support the position that the adulticidal heartworm treatment utilizing doxycycline and Advantage Multi®/Advocate® for Dogs (10% imidacloprid + 2.5% moxidectin) has successfully converted antigen-positive dogs to antigen-negative. To date, no controlled experimental studies have demonstrated the adulticidal efficacy of this treatment regimen. The aim of this study was to evaluate the parasitological and clinical efficacy of Advantage Multi® for Dogs (IMD + MOX) and doxycycline in heartworm-infected beagles. This study utilized 16 dogs, 8 dogs in each of non-treated control and treated groups. A total of 16 adult Dirofilaria immitis (Missouri strain) were surgically transplanted into the jugular vein of each study dog. The treatment regimen of monthly IMD + MOX topically (per labeled dosage and administration) for 10 months and 10 mg/kg doxycycline BID orally for 30 days was initiated 30 days post-surgical transplant. Echocardiograms, radiographs, complete blood counts, clinical chemistry profiles, heartworm antigenemia and microfilaremia were evaluated every 4 weeks. Serum samples were assayed for heartworm antigen using the DiroCHEK® heartworm antigen test. The DiroCHEK® was performed according to the manufac...Continue Reading

References

May 20, 2008·Advances in Parasitology·John W McCallLuigi Venco
Oct 22, 2008·Veterinary Parasitology·J W McCallB Carson

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Citations

Sep 8, 2019·Parasites & Vectors·Matthew J KrautmannJoseph F Boucher
Apr 25, 2020·Journal of Feline Medicine and Surgery·Maria Grazia PennisiKarin Möstl
Feb 15, 2020·Parasitology Research·Karin SonnbergerMichael Leschnik
Aug 14, 2021·Frontiers in Veterinary Science·Linda S Jacobson, Brian A DiGangi

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Methods Mentioned

BETA
ELISA

Software Mentioned

SAS®

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