Assessment of patent foramen ovale in carcinoid heart disease

American Heart Journal
Nicolas MansencalOlivier Dubourg

Abstract

Carcinoid syndrome may involve right carcinoid heart disease (CHD), secondary to the release of vasoactive substances. Left CHD is rare, as the inactivation of serotonin by the lung protects the left heart. We attempted to evaluate the prevalence of CHD and patent foramen ovale (PFO) with serial contrast transthoracic echocardiographic studies and to determine the markers of right and left CHD progression. Forty-one consecutive patients with proved digestive endocrine tumor and carcinoid syndrome were prospectively enrolled. All patients underwent serial conventional and contrast transthoracic echocardiographic studies. Right and left CHD, PFO, radiological examinations, and biological carcinoid markers were systematically assessed. Left CHD was present in 5 patients at baseline and in 13 patients (32%) during follow-up (P = .03). The 13 patients with left CHD also had PFO, and no left CHD occurred without PFO (P < .0001). Right CHD was present in 16 patients (39%) at baseline and in 25 patients (61%) at the end of follow-up (P = .04). The prevalence of right and left CHD was significantly higher in patients with PFO (88% and 76%, respectively; P < .04). A progression of right and left CHD was present, respectively, in 19 and 9...Continue Reading

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Citations

Sep 19, 2012·Cardiovascular Psychiatry and Neurology·Therese A KearyJohn Gunstad
Nov 10, 2012·Case Reports in Gastroenterology·Anton F EngelsmanAlex Katinakis
Oct 8, 2014·Internal and Emergency Medicine·Cristiano CarbonelliLuigi Zucchi
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Jul 14, 2007·International Journal of Cardiology·Kian Keong PohJudy Hung
Mar 27, 2007·Echocardiography·Bernard Abi-SalehSaid B Iskandar
Jan 23, 2009·International Journal of Cardiology·Nicolas MansencalOlivier Dubourg
Mar 25, 2008·The American Journal of Cardiology·Nicolas MansencalOlivier Dubourg
May 25, 2010·The American Journal of Cardiology·Nicolas MansencalOlivier Dubourg
Oct 17, 2014·Endocrine·Jan CalissendorffHenrik Falhammar
Jun 4, 2014·American Heart Journal·Chirdeep PatelAlfred A Bove
Apr 27, 2011·Journal of cardiovascular ultrasound·Hong-Won ShinKwon-Bae Kim
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Jun 28, 2019·Open Heart·Ali M AghaSaamir Hassan
Mar 6, 2019·Texas Heart Institute Journal·Pradhum RamGregg S Pressman
Nov 25, 2021·Journal of the American Heart Association·Emilie BaronNicolas Mansencal

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