Assessment of penile erection methods in rhesus macaques to model pharmacokinetics of antiretroviral drugs and penile infection with simian immunodeficiency virus

Journal of Medical Primatology
James HayesCharles W Dobard

Abstract

An established macaque model to assess HIV interventions against penile transmission is currently not available. Physiological changes during penile erections may affect susceptibility to infection and drug pharmacokinetics (PK). Here, we identify methods to establish erections in macaques to evaluate penile transmission, PK, and efficacy under physiologic conditions. Penile rigidity and length were evaluated in eight rhesus macaques following rectal electrostimulation (RES), vibratory stimulation (VS), or pharmacological treatment with Sildenafil Citrate (Viagra) or Alprostadil. Rectal electrostimulation treatment increased penile rigidity (>82%) and length (2.5 ± 0.58 cm), albeit the response was transient. In contrast, VS alone or coupled with Viagra or Alprostadil failed to elicit an erection response. Rectal electrostimulation treatment elicits transient but consistent penile erections in macaques. High rigidity following RES treatment demonstrates increased blood flow and may provide a functional model for penile PK evaluations and possibly simian immunodeficiency virus (SIV) transmission under erect conditions.

References

Jan 1, 1978·Journal of Medical Primatology·K G GouldD E Martin
Dec 1, 1974·Annals of Biomedical Engineering·H WarnerM E Keeling
Mar 20, 1972·JAMA : the Journal of the American Medical Association·A S Gale
Jan 1, 1982·Journal of Psychoactive Drugs·J Buffum
May 18, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S MeghdadiH Sinzinger
Jul 1, 2004·Journal of Asian Natural Products Research·Dong-Hui YangHong Liang
Feb 9, 2006·British Journal of Pharmacology·Gordon McMurrayAlasdair M Naylor
Sep 25, 2007·The Journal of Sexual Medicine·John P MulhallKyle Hvidsten
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Apr 8, 2010·Science Translational Medicine·J Gerardo García-LermaWalid Heneine
Jul 30, 2011·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·UNKNOWN National Association of EMS Physicians
Sep 12, 2012·Current Opinion in HIV and AIDS·J Gerardo García-Lerma, Walid Heneine
Apr 23, 2013·Journal of the Academy of Nutrition and Dietetics·Eleese Cunningham
May 15, 2013·Current Opinion in HIV and AIDS·Christine M Fennessey, Brandon F Keele
Nov 5, 2013·Ethology : Formerly Zeitschrift Für Tierpsychologie·Constance DubucDario Maestripieri
May 28, 2014·The Journal of Antimicrobial Chemotherapy·Peter L AndersonJ Gerardo García-Lerma
Jan 30, 2015·The Journal of Antimicrobial Chemotherapy·Ivana MassudJ Gerardo García-Lerma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.