Assessment of physical traits of rat offspring derived from mothers exposed to dioxin

Environmental Toxicology and Pharmacology
Joanna Rosińczuk, Ireneusz Całkosiński

Abstract

Negative effects of dioxin action are associated with limited abilities of their bio-degradation along with continuously increasing production and long-term bio-accumulation of those toxins in living organisms. Dioxins penetrate through placenta to fetus indicating indirect toxic effects on offspring of mothers exposed to the action of these toxins. During lactation a significant part of dioxins is excreted from organism with milk, which contributes to further accumulation of those compounds and multiple exceeding of maximal permissible dose of dioxins in newborns feeding with mother's milk. The aim of the study was to determine how a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to females 3 weeks before getting pregnant affects the parturition duration, labour delay, number and weight of offspring. The studies were performed on rat offspring deriving from primigravida females from the Buffalo strain, which 3 weeks before getting pregnant were administered with a single dose of TCDD. The obtained results revealed that labours in females exposed to dioxin effects were characterized by significant temporal range and their end occurred 3 weeks later compared to females from the control group, which gave b...Continue Reading

References

Mar 30, 2002·Cadernos de saúde pública·Ewa L Gregoraszczuk
Nov 2, 2005·Molecular and Cellular Biology·Takashi BabaYoshiaki Fujii-Kuriyama
Dec 6, 2008·Integrated Environmental Assessment and Management·Matthew J ZwiernikJohn P Giesy
Mar 13, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tisha C King HeidenRichard E Peterson

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