Assessment of Physiological Intracranial Calcification in Healthy Adults Using 18 F-NaF PET/CT

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Abdullah Al-ZaghalAbass Alavi

Abstract

The aim of this research study was to determine the role of 18F-Sodium fluoride (NaF) PET/CT imaging in the assessment of physiologic molecular calcification in the intra-cranial structures. We also examined the association of NaF accumulation with age as well as Hounsfield unit (HU) in certain anatomical sites that are known to calcify with normal aging. Methods: A total of 78 healthy subjects from the Cardiovascular Molecular Calcification Assessed by 18F-NaF PET/CT (CAMONA) clinical trial (38 females and 40 males) were included in this retrospective study. The mean age was 45.28 ±14.15 years (21-75). Mean standardized uptake values (SUVmean) was used to measure NaF accumulation in the choroid plexus and epithalamus (pineal gland and habenula). Maximum HU was also measured for each ROI. Correlation analysis was conducted to assess the association between parameters. Results: Mean SUVmean was 0.42 ± 0.26 in the right choroid plexus, 0.39 ±25 in the left choroid plexus, and 0.23±0.08 in the epithalamus. Significant positive correlations were present between NaF uptake and age in the right choroid plexus (r=0.61, P < 0.0001), left choroid plexus (r=0.63, p<0.0001), and epithalamus (r=0.36, P = 0.001). NaF uptake significantly co...Continue Reading

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Citations

Jul 10, 2019·Clinical Nuclear Medicine·Esha KothekarAbass Alavi
Mar 19, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Richard A P TakxJoline W Beulens
May 21, 2019·Clinical Nuclear Medicine·Esha KothekarJoshua F Baker
Oct 24, 2020·Diagnostics·Poul F Høilund-CarlsenOke Gerke

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