Assessment Of Plasma B-Catenin Concentration As Biomarker Of Thyroid Cancer

Polski przeglad chirurgiczny
Michał Bełdowski

Abstract

New diagnostic methods for thyroid diseases are still being searched for. Immunohistochemical diagnosis is expanded by the introduction of new biomarkers including ß-catenin (B-Cat). Associations are indicated between the cellular expression of this biomarker and tumor stage, nodal metastases and the degree of tumor cell differentiation. Reports are scarce regarding the plasma level of this biomarker in malignant neoplastic diseases. The aim of the study was to analyze the plasma B-Cat concentration and the possibility of it use in the diagnostics of patients with nodular goiter and papillary thyroid carcinoma. Plasma B-Cat concentration was determined in 64 patients with goiter and 15 healthy volunteers. The final histopathological examination revealed 41 cases of papillary thyroid carcinoma (PTC) and 13 cases of nodular goiter (NG). A significant increase in B-Cat (p <0.05) in both groups compared to the control group. No differences in the concentrations of biomarker was demonstrated between the PTC and NG groups. After determining the AUC for the tested biomarker, the B-Cat ratio of the area value 0.721 was the strong diagnostic test. Changes in the plasma B-Cat concentration can be the biomarker of thyroid cancer but it ca...Continue Reading

References

Oct 16, 1999·International Journal of Cancer. Journal International Du Cancer·J HusmarkM Nilsson
Feb 18, 2003·Endocrine Reviews·Orsolya DohánNancy Carrasco
Nov 4, 2004·Clinical Endocrinology·Jörg Bojunga, Stefan Zeuzem
Sep 1, 2006·Reviews in Endocrine & Metabolic Disorders·Mark L Johnson, Nalini Rajamannan
Mar 13, 2008·Structure·Cara J Gottardi, Mark Peifer
Mar 13, 2008·Structure·Yi XingWenqing Xu
Jul 9, 2008·World Journal of Gastroenterology : WJG·Adam ElzagheidSeppo Pyrhonen
Oct 19, 2010·Nucleic Acids Research·Simon A ForbesP Andrew Futreal
Dec 18, 2012·The International Journal of Neuroscience·Wenhao WuLiwei Zhang
Jan 1, 2014·Postȩpy higieny i medycyny doświadczalnej·Kamil Koziński, Agnieszka Dobrzyń
Jan 1, 2012·Central European Journal of Urology·Andrzej NowickiJoanna Duda-Szymańska
Mar 22, 2014·Molecular Endocrinology·Ana Sastre-Perona, Pilar Santisteban

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
O H BEAHRSB M BLACK
Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
R MAASS ESCOTO, S MARTINEZ
© 2021 Meta ULC. All rights reserved