Assessment of plasma concentrations and potential adverse effects of doxycycline in cockatiels (Nymphicus hollandicus) fed a medicated pelleted diet

Journal of Avian Medicine and Surgery
K FlammerMark G Papich

Abstract

Doxycycline hyclate was mixed with soybean oil and then added to a low-fat pelleted diet that contained approximately 2.4% fat, which produced a final diet that contained a calculated 6.4% fat and 300 mg doxycycline per kilogram of diet. The medicated diet was fed to 9 healthy adult cockatiels (Nymphicus hollandicus) for 47 days; a control group of 6 birds received the identical diet without doxycycline. Trough doxycycline plasma concentrations were measured 7 times during treatment and ranged from 0.98 to 3.83 microg/mL with an overall median of 2.09 microg/ mL. The birds were observed daily, weighed, and examined at least weekly, and selected plasma biochemical parameters were measured before treatment and at days 21 and 42. No adverse effects were noted, except one treatment bird became obese. This medicated diet may be suitable for treating spiral bacteria and Chlamydophila psittaci infections in cockatiels that will consume a pelleted diet.

References

Dec 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·J L Riond, J E Riviere
Sep 26, 1987·Lancet·R B Buttery, T G Wreghitt
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·W J Zeller, D Schmähl
Jul 1, 1995·Veterinary Microbiology·D VanrompayF Haesebrouck
Jan 7, 1998·Antimicrobial Agents and Chemotherapy·P ButayeF Haesebrouck
Jul 14, 2001·Antimicrobial Agents and Chemotherapy·J LenartD D Rockey
Jun 25, 2002·Toxicology and Applied Pharmacology·Ronald E BaynesJim E Riviere
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·R J SuchlandWalter E Stamm
Oct 14, 2003·Journal of the American Veterinary Medical Association·Keven FlammerMark Papich
Sep 25, 2004·Antimicrobial Agents and Chemotherapy·Jae DuganArthur A Andersen
Jan 24, 2006·Journal of the American Veterinary Medical Association·Diane E PreziosiShelley C Rankin
Feb 5, 2008·Journal of the American Veterinary Medical Association·Erika E EvansKeven Flammer
Aug 30, 2008·The Veterinary Record·A Di FrancescoR Cevenini
Dec 5, 2008·Veterinary Microbiology·Taher HarkinezhadDaisy Vanrompay
Feb 18, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D S A Beeckman, D C G Vanrompay
Aug 19, 2009·Antimicrobial Agents and Chemotherapy·R J SuchlandD D Rockey
May 26, 2010·Journal of Avian Medicine and Surgery·David Sanchez-Migallon GuzmanBranson Ritchie
Sep 24, 2010·Future Microbiology·Kelsi M Sandoz, Daniel D Rockey

❮ Previous
Next ❯

Citations

Aug 10, 2021·The Veterinary Clinics of North America. Exotic Animal Practice·David J McLelland, Jennifer M McLelland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.