Assessment of Plasma Proteomics Biomarker's Ability to Distinguish Benign From Malignant Lung Nodules: Results of the PANOPTIC (Pulmonary Nodule Plasma Proteomic Classifier) Trial

Chest
Gerard A SilvestriPANOPTIC Trial Team

Abstract

Lung nodules are a diagnostic challenge, with an estimated yearly incidence of 1.6 million in the United States. This study evaluated the accuracy of an integrated proteomic classifier in identifying benign nodules in patients with a pretest probability of cancer (pCA) ≤ 50%. A prospective, multicenter observational trial of 685 patients with 8- to 30-mm lung nodules was conducted. Multiple reaction monitoring mass spectrometry was used to measure the relative abundance of two plasma proteins, LG3BP and C163A. Results were integrated with a clinical risk prediction model to identify likely benign nodules. Sensitivity, specificity, and negative predictive value were calculated. Estimates of potential changes in invasive testing had the integrated classifier results been available and acted on were made. A subgroup of 178 patients with a clinician-assessed pCA ≤ 50% had a 16% prevalence of lung cancer. The integrated classifier demonstrated a sensitivity of 97% (CI, 82-100), a specificity of 44% (CI, 36-52), and a negative predictive value of 98% (CI, 92-100) in distinguishing benign from malignant nodules. The classifier performed better than PET, validated lung nodule risk models, and physician cancer probability estimates (P <...Continue Reading

Associated Clinical Trials

Citations

Sep 27, 2018·Molecular Omics·Liyuan PengEdouard C Nice
Feb 15, 2019·Cancers·Jonathan BenzaquenPaul Hofman
Apr 12, 2019·Current Opinion in Pulmonary Medicine·Faria Nasim, David E Ost
May 18, 2020·Proteomics. Clinical Applications·Roberto GasparriLorenzo Spaggiari
Oct 4, 2019·Journal of Extracellular Vesicles·Jia-Tao ZhangWen-Zhao Zhong
Nov 30, 2018·Nature Reviews. Clinical Oncology·Bing ZhangAmanda G Paulovich
Dec 6, 2019·Breathe·Nikolaos I Kanellakis, Kevin Lamote
Oct 10, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Derek BrownBríd M Ryan
Dec 17, 2020·Journal of Inherited Metabolic Disease·Anna SidorinaCarlo Dionisi-Vici
Oct 24, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Edwin J OstrinSamir M Hanash
Dec 3, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Robert C Bast, Sudhir Srivastava
Feb 6, 2020·Clinics in Chest Medicine·Catherine R Sears, Peter J Mazzone
Feb 23, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Daniel AjonaRuben Pio
Jul 30, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Iakovos ToumazisSylvia K Plevritis
Apr 4, 2021·Cancers·Mateusz Smolarz, Piotr Widlak
Jan 29, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoseop KimYoungsoo Kim
Apr 2, 2021·The Journal of Clinical Investigation·Wenhua LiangJianxing He
May 12, 2021·Current Opinion in Pulmonary Medicine·Rafael PaezPierre Massion
Sep 1, 2021·American Journal of Respiratory and Critical Care Medicine·Michael N KammerPierre P Massion
Jun 25, 2021·Journal of Bronchology & Interventional Pulmonology·David E Ost
Jan 19, 2022·JAMA : the Journal of the American Medical Association·Peter J Mazzone, Louis Lam

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Methods Mentioned

BETA
biopsy
surgical resection
PCA
biopsies

Software Mentioned

MATLAB
MedCalc
MathWorks

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