Assessment of platelet-derived thrombogenicity with the total thrombus-formation analysis system in coronary artery disease patients receiving antiplatelet therapy

Journal of Thrombosis and Haemostasis : JTH
Yuichiro ArimaHisao Ogawa

Abstract

Accurate evaluation of thrombogenicity helps to prevent thrombosis and excessive bleeding. The total thrombus-formation analysis system (T-TAS) was developed for quantitative analysis of platelet thrombus formation by the use of microchips with thrombogenic surfaces (collagen, platelet chip [PL-chip]; collagen plus tissue factor, atherome chip [AR-chip]). We examined the utility of the T-TAS in the assessment of the efficacy of antiplatelet therapy in patients with coronary artery disease (CAD). In this cross-sectional study, 372 consecutive patients admitted to the cardiovascular department were divided into three groups: patients not receiving any antiplatelet therapy (control, n = 56), patients receiving aspirin only (n = 69), and patients receiving aspirin and clopidogrel (n = 149). Blood samples were used for the T-TAS to measure the platelet thrombus-formation area under the curve (AUC) at various shear rates (1500 s(-1) [PL18 -AUC10 ] and 2000 s(-1) [PL24 -AUC10 ] for the PL-chip; 300 s(-1) [AR10 -AUC30 ] for the AR-chip). The on-clopidogrel platelet aggregation was measured by the use of P2Y12 reaction units (PRUs) with the VerifyNow system. The mean PL24 -AUC10 levels were 358 ± 111 (± standard deviation) (95% confiden...Continue Reading

References

Dec 1, 1996·Clinical Pharmacology and Therapeutics·T KubotaT Ishizaki
Mar 11, 2005·The New England Journal of Medicine·Marc S SabatineUNKNOWN CLARITY-TIMI 28 Investigators
May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Sep 6, 2005·Drug Metabolism and Pharmacokinetics·Hiromi Fukushima-UesakaJun-Ichi Sawada
Nov 8, 2005·Lancet·Z M ChenUNKNOWN COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) collaborative group
Dec 25, 2008·The New England Journal of Medicine·Tabassome SimonUNKNOWN French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators
Dec 25, 2008·The New England Journal of Medicine·Jessica L MegaMarc S Sabatine
Feb 14, 2009·The American Journal of Cardiology·Dominick J Angiolillo
Mar 5, 2009·JAMA : the Journal of the American Medical Association·P Michael HoJohn S Rumsfeld
Nov 26, 2009·Circulation·Jeffrey S BergerUNKNOWN CHARISMA Investigators
Feb 25, 2010·JAMA : the Journal of the American Medical Association·Nicoline J BreetJurriën M ten Berg
Mar 13, 2010·Journal of the American College of Cardiology·Dominick J AngiolilloAntonio Fernandez-Ortiz
May 31, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·S OgawaK A Tanaka
Nov 2, 2013·JAMA : the Journal of the American Medical Association·Fausto FeresUNKNOWN OPTIMIZE Trial Investigators
Nov 18, 2014·The New England Journal of Medicine·Laura MauriUNKNOWN DAPT Study Investigators

❮ Previous
Next ❯

Citations

Feb 23, 2018·Medicine and Science in Sports and Exercise·Kamil PrzyborowskiStefan Chlopicki
Jun 12, 2018·Journal of Thrombosis and Haemostasis : JTH·R HartmannF Scheiflinger
Apr 12, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinya IchikawaKazuo Kimura
Aug 9, 2019·Journal of Atherosclerosis and Thrombosis·Tatsuro MitsuseKenichi Tsujita
Nov 7, 2019·Journal of Atherosclerosis and Thrombosis·Masako Yamazaki
Sep 20, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Daisuke SuetaUNKNOWN ESCORT-TKA Study Investigators
Aug 23, 2020·Journal of Clinical Medicine·Jessica Le BlancMarie Lordkipanidzé
Jun 26, 2020·Frontiers in Veterinary Science·Tomoko IwanagaRobert Goggs
Jun 3, 2021·Scientific Reports·Munehisa ShimamuraRyuichi Morishita
Jul 26, 2019·Analytical Chemistry·Crispin SzydzikWarwick S Nesbitt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.