Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift

Environmental and Molecular Mutagenesis
Maria Helena Guerra AndersenPeter Møller

Abstract

Firefighting is regarded as possibly carcinogenic, although there are few mechanistic studies on genotoxicity in humans. We investigated exposure to polycyclic aromatic hydrocarbons (PAH), lung function, systemic inflammation and genotoxicity in peripheral blood mononuclear cells (PBMC) of 22 professional firefighters before and after a 24-h work shift. Exposure was assessed by measurements of particulate matter (PM), PAH levels on skin, urinary 1-hydroxypyrene (1-OHP) and self-reported participation in fire extinguishing activities. PM measurements indicated that use of personal protective equipment (PPE) effectively prevented inhalation exposure, but exposure to PM occurred when the environment was perceived as safe and the self-contained breathing apparatuses were removed. The level of PAH on skin and urinary 1-OHP concentration were similar before and after the work shift, irrespective of self-reported participation in fire extinction activities. Post-shift, the subjects had reduced levels of oxidatively damaged DNA in PBMC, and increased plasma concentration of vascular cell adhesion molecule 1 (VCAM-1). The subjects reporting participation in fire extinction activities during the work shift had a slightly decreased lung f...Continue Reading

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Citations

Jun 12, 2019·Particle and Fibre Toxicology·Maria Helena Guerra AndersenUlla Vogel
Dec 17, 2020·International Journal of Environmental Research and Public Health·Carla RussoMassimo Moretti
Jan 9, 2021·Particle and Fibre Toxicology·Hao ChenHaiyan Tong
Jun 3, 2021·International Journal of Environmental Research and Public Health·Po-Hsuan JengWei-Liang Chen
Oct 28, 2021·Chemical Research in Toxicology·Peter Møller, Martin Roursgaard

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