PMID: 11093291Nov 28, 2000

Assessment of postprandial hepatic glycogen synthesis from uridine diphosphoglucose kinetics in obese and lean non-diabetic subjects

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
N PaquotL Tappy


Obese patients are frequently characterized by insulin resistance and decreased insulin-mediated glycogen synthesis in skeletal muscle. Whether they also have impaired postprandial hepatic glycogen synthesis remains unknown. To determine whether postprandial hepatic glycogen synthesis is decreased in obese patients compared to lean subjects. Lean and obese subjects with impaired glucose tolerance were studied over 4h after ingestion of a glucose load. Hepatic uridine diphosphoglucose kinetics were assessed using 13C-galactose infusion, with monitoring of urinary acetaminophen-glucuronide isotopic enrichment to estimate hepatic glycogen kinetics. Estimated net hepatic glycogen synthesis amounted to 18.6 and 22.6% of the ingested load in lean and obese subjects, respectively. Postprandial hepatic glycogen metabolism is not impaired in non-diabetic obese subjects.


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Related Concepts

Blood Glucose
Nonesterified Fatty Acids
Insulin Sensitivity
Liver Glycogen
Uridine Diphosphate Glucose
Impaired Glucose Tolerance
Postprandial Period

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