Assessment of PrEP eligibility and uptake among at-risk MSM participating in a HIV-1 vaccine feasibility cohort in coastal Kenya.

Wellcome Open Research
Elizabeth WahomeEduard J Sanders

Abstract

Introduction: Pre-exposure prophylaxis (PrEP) is provided free of costs to at-risk populations in Kenya, including men who have sex with men (MSM), but anal intercourse is not an eligibility criterion. We set out to determine PrEP eligibility, uptake and predictors of PrEP uptake among MSM enrolled in an HIV-1 vaccine feasibility cohort in coastal Kenya. Methods: We compared the number of MSM identified as eligible for PrEP from June-December 2017 by Kenyan Ministry of Health (MoH) criteria, which do not include reported anal intercourse, to those identified as eligible by a published MSM cohort-derived HIV-1 risk score (CDHRS). We determined PrEP uptake and assessed factors associated with uptake at first offer among eligible MSM followed up monthly. Results: Out of 167 MSM assessed for PrEP eligibility, 118 (70.7%) were identified by both MoH and CDHRS eligibility criteria; 33 (19.8%) by CDHRS alone, 11 (6.6%) by MoH criteria alone, and 5 (3.0%) by neither criterion. Of the men identified by CDHRS alone, the majority (24 or 72.7%) reported receptive anal intercourse (RAI). Of the 162 MSM eligible for PrEP, 113 (69.7%) accepted PrEP at first offer. Acceptance of PrEP was higher for men reporting RAI (adjusted prevalence ratio ...Continue Reading

References

Nov 21, 2007·AIDS·Eduard J SandersAdrian D Smith
Apr 22, 2010·International Journal of Epidemiology·Rebecca F BaggaleyMarie-Claude Boily
Jan 10, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew A PriceEduard J Sanders
Mar 13, 2014·Journal of Sex Research·Zoe Duby, Christopher Colvin
Nov 18, 2015·Current Opinion in HIV and AIDS·Nelly R MugoNduku Kilonzo
Apr 19, 2017·Journal of the International AIDS Society·Brenda HoaglandUNKNOWN PrEP Brasil Study TeamClinical Trial Number 01989611
Mar 6, 2018·The Journal of Infectious Diseases·Erik M VolzUNKNOWN UK HIV Drug Resistance Database
Nov 9, 2018·Sexual Health·Sarah MasyukoOn Behalf Of The PrEP Technical Working Group

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