Assessment of Pulp Regeneration Induced by Stem Cell Therapy by Magnetic Resonance Imaging

Journal of Endodontics
Koichiro IoharaM Nakashima

Abstract

This study was designed to evaluate the usefulness of magnetic resonance imaging (MRI) to assess the regeneration of pulp tissue. Mobilized dental pulp stem cells and granulocyte colony-stimulating factor with collagen were transplanted into mature pulpectomized teeth for pulp regeneration (n = 4). The controls consisted of pulpectomized teeth with or without collagen and normal teeth with intact pulp tissue (n = 4, each). The signal intensity (SI) of MRI using T2 sequences was compared after the extraction of teeth in dogs. MRI was correlated with the corresponding histologic findings. Pulp tissue was fully regenerated 90 days after cell transplantation. On the other hand, the root canal was empty in the control collagen-transplanted teeth at 90 days. The SI of the normal teeth was significantly higher than that of nonvital pulpectomized teeth and the controls of collagen transplanted teeth at 90 days. The stem cell transplanted teeth showed a gradual decrease in the SI until 180 days at which time the SI was similar to that in the normal teeth and significantly higher than that in the teeth transplanted with collagen alone without the stem cells. The changes in the SI of the pulplike tissue were consistent with the histologic...Continue Reading

References

Jun 2, 1998·Journal of Computer Assisted Tomography·C NaselH Imhof
Sep 12, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·O PloderA Baumann
Nov 10, 2004·Dento Maxillo Facial Radiology·B KressK Sartor
Dec 21, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Bodo KressMarc Schmitter
Mar 21, 2007·Journal of Endodontics·Peter E MurrayKenneth M Hargreaves
Feb 27, 2008·International Endodontic Journal·J Lin, N P Chandler
Jul 27, 2011·Journal of Endodontics·Djaudat IdiyatullinDonald R Nixdorf
Nov 22, 2011·Journal of Endodontics·Eugene Chen, Paul V Abbott
Aug 31, 2012·Radiology and Oncology·Dusan Sustercic, Igor Sersa
Sep 26, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Kerstin GerlachUta Delling
Mar 6, 2013·Journal of Endodontics·Kenneth M HargreavesFabricio B Teixeira
Mar 6, 2013·Journal of Endodontics·Alan S Law
Jun 14, 2013·Stem Cells Translational Medicine·Koichiro IoharaMisako Nakashima
May 20, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Alexandre T AssafJan Sedlacik
Jul 15, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Alexandre T AssafReinhard E Friedrich
Aug 9, 2015·Journal of Dental Research·A A VolponiP T Sharpe
Aug 28, 2015·Journal of Dental Research·Y CaoM K Kang

❮ Previous
Next ❯

Citations

Oct 1, 2016·Stem Cells International·Jessica RatajczakPetra Hilkens
Mar 11, 2017·Stem Cell Research & Therapy·Misako NakashimaKenji Matsushita
Aug 14, 2020·Clinical Oral Investigations·Christoph RoserAlexander Juerchott
Nov 30, 2018·Oral Radiology·Yoshiko ArijiKoichiro Iohara
Mar 19, 2020·Stem Cells International·Geraldine M AhmedKarim Fawzy El-Sayed
Sep 21, 2020·Journal of Endodontics·Gottfried SchmalzKerstin M Galler
Apr 23, 2021·Tissue Engineering. Part B, Reviews·Francesca MangioneSibylle Vital
May 1, 2021·International Journal of Molecular Sciences·Sahng G Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.