Assessment of quantitative magnetic resonance imaging metrics in the brain through the use of a novel phantom

Brain Injury : [BI]
Elisabeth A WildeWalter Schneider

Abstract

Multisite and longitudinal neuroimaging studies are important in uncovering trajectories of recovery and neurodegeneration following traumatic brain injury (TBI) and concussion through the use of diffusion tensor imaging (DTI) and other imaging modalities. This study assessed differences in anisotropic diffusion measurement across four scanners using a human and a novel phantom developed in conjunction with the Chronic Effects of Neurotrauma Consortium. Human scans provided measurement within biological tissue, and the novel physical phantom provided measures of anisotropic intra-tubular diffusion to serve as a model for intra-axonal water diffusion. Intra- and inter-scanner measurement variances were compared, and the impact on effect size was calculated. Intra-scanner test-retest reliability estimates for fractional anisotropy (FA) demonstrated relative stability over testing intervals. The human tissue and phantom showed similar FA ranges, high linearity and large within-device effect sizes. However, inter-scanner measures of FA indicated substantial differences, some of which exceeded typical DTI effect sizes in mild TBI. The diffusion phantom may be used to better elucidate inter-scanner variability in DTI-based measuremen...Continue Reading

References

May 1, 1997·Medical Physics·W DabrowskiA Fenster
May 8, 2001·Medical Physics·W D D'SouzaB R Thomadsen
Feb 5, 2005·Journal of Digital Imaging·Chien-Chuan ChenHo-Ling Liu
Jun 27, 2006·Psychiatry Research·Stefano MarencoDaniel R Weinberger
Mar 29, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Seppo MattilaAntti Tarkiainen
Nov 28, 2007·AJNR. American Journal of Neuroradiology·D R RutgersD Ducreux
Feb 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Carolin ReischauerPeter Boesiger
Jan 28, 2010·Journal of Rehabilitation Research and Development·Robert W Van BovenMichael W Weiner
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Elisabetta PaganiMassimo Filippi
Mar 11, 2011·Human Brain Mapping·Hidemasa TakaoKuni Ohtomo
Jul 27, 2011·Journal of Neurotrauma·Jill V HunterBarbara A Holshouser
Sep 20, 2011·Journal of Magnetic Resonance Imaging : JMRI·Thomas L ChenevertBrian D Ross
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Nov 25, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gene Y ChoEric E Sigmund
Oct 2, 2012·Journal of Magnetic Resonance Imaging : JMRI·Dariya MalyarenkoThomas L Chenevert
Apr 12, 2013·Journal of Magnetic Resonance Imaging : JMRI·Ioannis LavdasEric O Aboagye
Dec 19, 2013·PloS One·Fang-Cheng YehWen-Yih Isaac Tseng
Mar 19, 2014·Brain Structure & Function·Juan C Fernández-MirandaFang-Cheng Yeh
Jun 13, 2014·Statistical Methods in Medical Research·Larry G KesslerUNKNOWN QIBA Terminology Working Group
Jun 13, 2014·Statistical Methods in Medical Research·Nancy A ObuchowskiUNKNOWN Algorithm Comparison Working Group
Jun 13, 2014·Statistical Methods in Medical Research·David L RaunigUNKNOWN QIBA Technical Performance Working Group
Dec 23, 2016·AJNR. American Journal of Neuroradiology·E M PalaciosUNKNOWN TRACK-TBI Investigators

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