Assessment of radical activity during the acute phase of myocardial infarction following fibrinolysis: utility of assaying plasma malondialdehyde

Free Radical Biology & Medicine
S PucheuJ de Leiris

Abstract

Numerous experimental and clinical studies have reported a role of radical forms of oxygen in the etiology of the manifestations of reperfusion of the ischemic myocardium. However, clinical results remain controversial. The aim of this study was to ascertain the existence of reperfusion-related radical stress after thrombolysis with a marker that is easy to use and reliable. Thirty patients hospitalized for acute myocardial infarction were involved in the study. Of these, 18 had been subjected to intravenous thrombolysis (Group I) and 12 had not (Group II). They were compared to two control groups who had no history of myocardial infarction. Of these, 16 were patients with coronary heart disease hospitalized for stable angina (Group III) and 17 were patients free of any known cardiovascular disease (Group IV). Radical activity was assessed in plasma samples taken from a peripheral vein over a 10-day period of hospitalization by measuring (1) malondialdehydes (MDA) concentrations using fluorometry techniques or HPLC, (2) the antioxidant activity of glutathione peroxidase (GPx) and (3) the concentration of various antiradical compounds (beta-carotene, vitamins A and E, uric acid). All patients in Group I had a patent artery on co...Continue Reading

References

Apr 1, 1992·Molecular and Cellular Biochemistry·C CeconiR Ferrari
May 1, 1990·The Journal of Nutrition·C D DavisJ L Greger
Jun 1, 1989·The Annals of Thoracic Surgery·P Menasché, A Piwnica
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J L ZweierM L Weisfeldt
Jan 1, 1988·Free Radical Biology & Medicine·A S Manning
Jul 1, 1988·Journal of the American College of Cardiology·R Bolli
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Dec 1, 1982·Circulation·E Braunwald, R A Kloner
Jun 1, 1983·Journal of Clinical Pathology·J AznarJ Sala
Jun 1, 1994·American Heart Journal·E D GrechD R Ramsdale
Dec 1, 1958·Circulation·C B CHAPMANF J BONTE

❮ Previous
Next ❯

Citations

Jun 27, 2003·Free Radical Biology & Medicine·S ServaisRoland Favier
Jan 16, 1999·Free Radical Biology & Medicine·L L de ZwartN P Vermeulen
Apr 28, 1999·Free Radical Biology & Medicine·V P PalaceP K Singal
Sep 1, 1999·Kidney International·M BoazS Smetana
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·D T Lucas, L I Szweda
Jul 28, 2009·Heart Failure Clinics·Barry H Trachtenberg, Joshua M Hare
Jul 16, 2008·Expert Opinion on Therapeutic Targets·P GeorgiadouD Th Kremastinos
May 18, 2016·Mediators of Inflammation·Binfeng HeXiaolan Guo
Apr 9, 2015·Basic Research in Cardiology·Manolis MavroidisYassemi Capetanaki
Jun 5, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Premysl MladenkaRadomir Hrdina
Oct 26, 2016·Journal of Cardiovascular and Thoracic Research·Hassanali LotfollahiMehri Roshani
Jul 5, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sevgi Yardim-AkaydinMeral Torun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.