Assessment of radical scavenging capacity and lipid peroxidation inhibiting capacity of antioxidant

Journal of Agricultural and Food Chemistry
Etsuo NikiYasukazu Yoshida

Abstract

The role of radical scavenging antioxidants against oxidative stress has received much attention, and the antioxidant capacity has been assessed by various methods. Among them, a method that measures the effect of antioxidant on decay of the probe is one of the most widely used methods. The present study was performed to compare the two methods to assess the antioxidant capacity, one to follow the decay of the probe and the other to measure lipid peroxidation products in human plasma. It was shown that the method following probe decay was suitable for assessment of radical scavenging capacity of antioxidant, but not for the capacity to inhibit lipid peroxidation in plasma. This is true whether a hydrophilic or lipophilic probe is used. Such different results arise from the fact that the efficacy of inhibition of lipid peroxidation by antioxidants depends on the fate of antioxidant-derived radical and interaction between antioxidants as well as the capacity of free radical scavenging. Thus, the capacity of antioxidants for inhibition of lipid peroxidation should be assessed from the effect on the extent of oxidation, not from the effect on probe decay.

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Citations

May 23, 2012·PloS One·Tuul SeppPeeter Hõrak
Jan 24, 2013·Journal of Clinical Biochemistry and Nutrition·Yasukazu YoshidaMototada Shichiri
Apr 11, 2012·BioFactors·Mizuki TakashimaEtsuo Niki
Oct 12, 2013·Redox Report : Communications in Free Radical Research·Koji FukuiShiro Urano
Oct 19, 2010·Chemistry and Physics of Lipids·Ilya PinchukDov Lichtenberg
Sep 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Max RomeroCamilo López-Alarcón
Jan 28, 2020·Journal of Epidemiology·Megumi Tsubota-UtsugiTakayoshi Ohkubo
May 5, 2011·The Journal of Physical Chemistry. B·Gabriela VelásquezAlexis Aspée

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