Assessment of recovery following a novel partial nerve lesion in a rat model

Muscle & Nerve
Tejashree S MalushteMark H Gonzalez

Abstract

Partial nerve lesions with a varying degree of retained function and often a painful neuroma pose a dilemma for the clinician. Surgical treatment of partial nerve lesion is perilous because of possible damage to intact axons and subsequent loss of retained function. We present a new rat model of a partial nerve lesion, allowing further study to improve treatment for this condition. A partial (50%) lesion of the tibial portion of the rat sciatic nerve was created and compared to standard crush and neurectomy control lesions. The extent of lost function and the progress of postoperative recovery following the three lesions were compared using serial walking track analyses and end-point muscle weight ratios for atrophy as outcome measures. All groups had tibial functional indices (TFI) significantly different from one another after 1 week. TFIs for the crush group returned to normal by 4 weeks, whereas the neurectomy group showed no recovery. The partial lesion group gradually improved, reaching a plateau of 44% by 7 weeks. Gastrocnemius muscle weight ratios for the partial, crush, and neurectomy lesions at 9 weeks were 0.63, 0.87, and 0.32, respectively. There was a strong correlation between the TFI and muscle weight ratios (r(2...Continue Reading

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Citations

Aug 10, 2013·Journal of Neuroscience Methods·Jonathan IsaacsSagar Shah
Aug 31, 2007·American Journal of Physiology. Renal Physiology·Margot S DamaserJames M Kerns
May 31, 2007·Anatomia, histologia, embryologia·A RuppK Matiasek
Nov 5, 2011·Journal of Anatomy·Hayley M BritzDavid M L Cooper
Jun 27, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Francesca ToiaMaurizio Calcagni
May 15, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael R DaviesBrian T Feeley
Jun 20, 2008·Journal of Neuroscience Methods·David HulataJames M Kerns
Jan 11, 2017·Muscle & Nerve·Jonathan IsaacsNikhil Pasula
Sep 5, 2014·The Journal of Bone and Joint Surgery. American Volume·Jonathan IsaacsBarrett Little
Mar 23, 2020·The Journal of Surgical Research·Jacqueline S IsraelSamuel O Poore

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