PMID: 7336676Jan 1, 1981Paper

Assessment of red cell autoantibodies in autoimmune hemolytic anemia of warm type by a radioactive anti-IgG test

Vox Sanguinis
N SchmitzC Mueller-Eckhardt

Abstract

To evaluate the applicability of a radioactive 125I-anti-IgG test (RIAT) for the detection of small amounts of IgG antibodies on red blood cells (RBC) of patients with autoimmune hemolytic anemia of warm type (AIHA), RBC of 125 patients were studied (AIHA, n = 53; Coombs'-negative AIHA, n = 6; chronic cold agglutinin disease, n = 7; non-immune anemias, n = 59). It was found that the RBC of all cases (33/33) with a positive direct IgG antiglobulin test (DAT-IgG), but also 13 out of 20 patients with a negative DAT-IgG, but detectable complement (C3/C4), and 4 out of 6 cases with Coombs'-negative AIHA gave positive results in the direct RIAT. RBC-associated IgG was higher in the DAT-IgG positive group (n = 33; -x = 8.1%) than in the DAT-IgG negative group (n = 26; -x3.4%). There was no correlation between hypergammaglobulinemia and RBC-associated IgG. The sensitivity of the indirect RIAT was not remarkable better as compared to the indirect antiglobulin test. The RIAT is valuable in the serology of borderline cases of AIHA.

References

May 1, 1978·The Journal of Clinical Investigation·R J KurlanderG L Logue
Jan 1, 1978·Journal of Immunological Methods·C Mueller-EckhardtI Mahn
Jun 1, 1978·British Journal of Haematology·S M Worlledge
Jul 29, 1971·The New England Journal of Medicine·B C GillilandR S Evans
May 1, 1970·The Journal of Clinical Investigation·B C GillilandJ H Vaughan
Sep 1, 1972·British Journal of Haematology·S M Worlledge, M A Blajchman
Jan 1, 1963·Journal of Clinical Pathology·H RUBIN

❮ Previous
Next ❯

Citations

Jan 15, 2014·Blood Cells, Molecules & Diseases·George B Segel, Marshall A Lichtman
Nov 7, 2007·Journal of Pediatric Hematology/oncology·Douglas P Blackall
Oct 20, 2004·American Journal of Clinical Pathology·Christine A WheelerDouglas P Blackall
Mar 27, 2009·Transfusion·Jeong-Shi LinTzeon-Jye Chiou
Jun 15, 2007·British Journal of Haematology·Morie A Gertz
Jan 1, 1984·Vox Sanguinis·S PanzerC Mueller-Eckhardt
Mar 1, 1982·Tissue Antigens·A SalamaC Mueller-Eckhardt
Mar 26, 2013·American Journal of Clinical Pathology·Marco LaiRaffaele Landolfi
Mar 29, 2002·American Journal of Hematology·Bradley C Gehrs, Richard C Friedberg
Jan 1, 1985·Critical Reviews in Oncology/hematology·R J Sokol, S Hewitt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.