Assessment of regional lung function impairment in airway obstruction and pulmonary embolic dogs with combined noncontrast electrocardiogram-gated perfusion and gadolinium diethylenetriaminepentaacetic acid aerosol magnetic resonance images

Journal of Magnetic Resonance Imaging : JMRI
Nobuhiko OgasawaraNaofumi Matsunaga

Abstract

To define regional function impairment in airway obstruction (AO) and pulmonary embolic (PE) dogs with a combination study of noncontrast electrocardiogram (ECG)-gated perfusion and gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) aerosol magnetic resonance (MR) images. After acquisition of multiphase fast-spin-echo (FSE) MR images during cardiac cycles in 14 AO dogs and 19 PE dogs, ECG-gated perfusion-weighted (PW) images were obtained by subtraction between two-phase images of the minimum lung signal intensity (SI) during systole and maximum SI during diastole. Each dog subsequently inhaled Gd-DTPA aerosol for 20 minutes, and subtracted Gd-DTPA aerosol images were obtained from precontrast and maximally enhanced images. ECG-gated PW images were compared with intravenous Gd-DTPA-enhanced pulmonary arterial perfusion phase (PAPP) images. ECG-gated PW images were consistent with Gd-DTPA-enhanced PAPP images in all dogs, with significant correlations in the affected-to-unaffected lung perfusion ratios (P < 0.005). Gd-DTPA aerosol images showed sufficient and uniform enhancement in the unaffected lungs. In all the AO areas, these combined images showed the matched perfusion and aerosol deposition defects. These images showe...Continue Reading

References

Feb 1, 1989·Journal of Applied Physiology·W MacNeeJ C Hogg
Mar 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N W RizkJ F Murray
Nov 1, 1995·Clinical Nuclear Medicine·K SugaT Nakanishi
Apr 30, 1998·Journal of Magnetic Resonance Imaging : JMRI·M MiyazakiY Machida
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y CrémillieuxA Briguet
Jul 14, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M ViallonY Crémillieux
Aug 1, 2000·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·W G SchreiberH U Kauczor
Oct 26, 2000·Journal of Magnetic Resonance Imaging : JMRI·M MiyazakiH Abe
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Kazuyoshi SugaNaofumi Matsunaga
Jul 1, 1964·Journal of Applied Physiology·J B WESTA NAIMARK

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Citations

Jun 15, 2012·Insights Into Imaging·Sebastian Ley, Julia Ley-Zaporozhan
Apr 3, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Richard B Thompson, Warren H Finlay
Mar 8, 2011·Academic Radiology·Yuka OkajimaHiroto Hatabu
Nov 1, 2008·Contrast Media & Molecular Imaging·Karim MosbahYannick Crémillieux
Apr 1, 2008·Cancer Control : Journal of the Moffitt Cancer Center·Geoffrey ZhangKenneth M Forster

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