PMID: 7541690Apr 1, 1995Paper

Assessment of renal dopaminergic system activity in the nitric oxide-deprived hypertensive rat model

British Journal of Pharmacology
P Soares-da-SilvaA Albino-Teixeira

Abstract

1. The present paper reports changes in the urinary excretion of dopamine, 5-hydroxytryptamine and amine metabolites in nitric oxide deprived hypertensive rats during long-term administration of NG-nitro-L-arginine methyl ester (L-NAME). Aromatic L-amino acid decarboxylase (AAAD) activity in renal tissues and the ability of newly-formed dopamine to leave the cellular compartment where the synthesis of the amine has occurred were also determined. 2. Twenty four hours after exposure to L-NAME, both systolic (SBP) and diastolic (DBP) blood pressure were increased by 20 mmHg; heart rate was slightly decreased. During the next 13 days both SBP and DBP increased progressively reaching 170 +/- 3 and 116 +/- 3 mmHg, respectively. 3. Baseline urinary excretion of L-DOPA, dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), 3-methoxytyramine (3-MT) and homovanillic acid (HVA) during the 4 day period of stabilization averaged 4.4 +/- 0.5, 13.8 +/- 0.3, 37.4 +/- 0.8, 180.0 +/- 2.7 and 206.1 +/- 6.7 nmol day-1, respectively. The urinary excretion of L-DOPA, dopamine and DOPAC, but not that of 3-MT and HVA, were increased from day 6-8 of L-NAME administration onwards (L-DOPA, up to 13.4 +/- 2.1; dopamine, up to 23.0 +/- 1.6; DOPAC, up to 62.8 +...Continue Reading

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Citations

Sep 12, 2000·Current Hypertension Reports·P A JoseR A Felder
Nov 28, 1997·Biochemical Pharmacology·P Soares-da-SilvaM P Serrão
Feb 26, 2000·Acta Physiologica Scandinavica·R A FelderP A Jose
Mar 4, 2000·Clinical and Experimental Pharmacology & Physiology·S YuasaH Matsuo
Aug 8, 2002·Clinical and Experimental Pharmacology & Physiology·Maria de los Angeles CostaC T Arranz
Apr 25, 2001·Kidney International·M A Vieira-CoelhoP Soares-da-Silva
Aug 1, 1995·British Journal of Pharmacology·M PestanaP Soares-da-Silva
Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cláudia CavadasEric Grouzmann
Jan 1, 1997·Clinical and Experimental Hypertension : CHE·P C Pinto-do-OA M Bertorello
Jan 1, 1997·Clinical and Experimental Hypertension : CHE·M A Vieira-CoelhoP Soares-da-Silva
Jul 12, 2002·Clinical and Experimental Hypertension : CHE·V A Lucas-TeixeiraM F Lokhandwala
Aug 11, 2000·Clinical and Experimental Hypertension : CHE·V A Lucas-TeixeiraP Soares-da-Silva
Jan 25, 2016·Journal of the American Society of Hypertension : JASH·Bruno IgrejaPatricio Soares-da-Silva
Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A FerreiraP Soares-Da-Silva
Dec 11, 2008·Basic & Clinical Pharmacology & Toxicology·Eduardo MouraMaria Augusta Vieira-Coelho
Apr 12, 2005·Life Sciences·Eduardo MouraMaria A Vieira-Coelho
Apr 10, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nuno Miguel PiresPatrício Soares-da-Silva
Mar 3, 2015·The Journal of Nutritional Biochemistry·Andreia GomesLaura Ribeiro
Oct 10, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bruno IgrejaPatrício Soares-da-Silva
Jan 28, 2006·European Journal of Pharmacology·Manuela MoratoAntónio Albino-Teixeira
Apr 21, 2005·The British Journal of Dermatology·S MaginaM Pestana
Apr 18, 2018·Neurourology and Urodynamics·Ana CoelhoFrancisco Cruz
Jul 24, 2004·American Journal of Physiology. Renal Physiology·Patrício Soares-da-Silva, Maria Paula Serrão
Oct 16, 1999·Hypertension·M A Vieira-CoelhoM F Lokhandwala
Feb 1, 2007·American Journal of Physiology. Renal Physiology·Maria João PinhoPatrício Soares-da-Silva
Sep 21, 2000·American Journal of Physiology. Renal Physiology·P Soares-Da-Silva, M P Serrão
Mar 5, 1998·The American Journal of Physiology·P Soares-Da-SilvaM A Vieira-Coelho
Jul 25, 2007·Molecular and Cellular Biochemistry·Maria João PinhoPatrício Soares-da-Silva
Jun 2, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Rita MatosAna Charrua

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