Assessment of renal dopaminergic system activity during the recovery of renal function in human kidney transplant recipients

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
M PestanaP Soares-Da-Silva

Abstract

The urinary excretion of free dopamine has been used as an index of the renal synthesis of amine. However, it is now well recognized that in the kidney, newly-formed dopamine is significantly inactivated through deamination to 3,4-dihydroxyphenylacetic acid (DOPAC) by monoamine oxidase (MAO). The aim of the present study was to assess the renal dopaminergic system activity during the recovery of renal function in kidney transplant recipients and to assess which parameters are appropriate for the evaluation of renal amine synthesis under these conditions. Twenty-four-hour urinary excretion of L-DOPA, dopamine and its metabolites (DOPAC; 3-MT; HVA) were continuously monitored in 19 renal transplant recipients from the first day of surgery until the twelfth day post-transplantation. In 11 patients (Group 1), renal function consistently recovered throughout the study (plasma creatinine levels decreased from 6.2 +/- 0.4 to 2.1 +/- 0.1 mg/dl). Eight patients presented with acute tubular necrosis (Group 2) and minimal renal function was maintained until the twelfth post-operative day. The urinary excretion of L-DOPA did not differ throughout the study between the two groups of patients. In contrast, the 24-h urinary levels of dopamine...Continue Reading

Citations

Sep 4, 1999·Clinical and Experimental Pharmacology & Physiology·M HayashiK Shimamoto
Oct 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Benedita Sampaio-MaiaManuel Pestana
May 10, 2000·Clinical and Experimental Hypertension : CHE·P Soares-da-SilvaM Cerqueira-Gomes
Apr 26, 2003·Acta Physiologica Scandinavica·B Sampaio-MaiaM Pestana
Oct 16, 1999·Hypertension·M A Vieira-CoelhoM F Lokhandwala
Feb 1, 2007·American Journal of Physiology. Renal Physiology·Maria João PinhoPatrício Soares-da-Silva
Nov 30, 2000·American Journal of Physiology. Renal Physiology·M A Vieira-CoelhoP Soares-da-Silva

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