Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Feng WangTakamune Takahashi

Abstract

Renal fibrosis is a hallmark of progressive renal disease; however, current clinical tests are insufficient for assessing renal fibrosis. Here we evaluated the utility of quantitative magnetization transfer MRI in detecting renal fibrosis in a murine model of progressive diabetic nephropathy (DN). The db/db eNOS-/- mice, a well-recognized model of progressive DN, and normal wild-type mice were imaged at 7T. The quantitative magnetization transfer data were collected in coronal plane using a 2D magnetization transfer prepared spoiled gradient echo sequence with a Gaussian-shaped presaturation pulse. Parameters were derived using a two-pool fitting model. A normal range of cortical pool size ratio (PSR) was defined as Mean±2SD of wild-type kidneys (N = 20). The cortical regions whose PSR values exceeded this threshold (threshold PSR) were assessed. The correlations between the PSR-based and histological (collagen IV or picrosirius red stain) fibrosis measurements were evaluated. Compared with wild-type mice, moderate increases in mean PSR values and scattered clusters of high PSR region were observed in cortex of DN mouse kidneys. Abnormally high PSR regions (% area) that were detected by the threshold PSR were significantly incr...Continue Reading

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Citations

Mar 7, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Feng WangJohn C Gore
Apr 15, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jakob Assländer
Sep 19, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Atul S MinhasHarish Poptani
Jul 25, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P HuangJ Wang
Sep 24, 2020·Journal of Magnetic Resonance Imaging : JMRI·Kai JiangLilach O Lerman
Feb 1, 2021·Medical Image Analysis·Israa AlnazerChristine Fernandez-Maloigne
Feb 23, 2021·Drug Discovery Today·Anjali SrivastavaShrikant R Mulay
Apr 10, 2021·Clinical and Experimental Nephrology·Daisuke KatagiriTakamune Takahashi
Jul 3, 2021·Journal of Clinical Medicine·José María Mora-GutiérrezNuria Garcia-Fernandez

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