Assessment of renal function in living kidney donors before and after nephrectomy: A Japanese prospective, observational cohort study

International Journal of Urology : Official Journal of the Japanese Urological Association
Yoichi KakutaK Tanabe

Abstract

To investigate the utility of estimated glomerular filtration rate for assessing kidney function in living kidney donors before and after nephrectomy. A total of 101 donors underwent inulin clearance measurements before and 1 year after nephrectomy. The mean of three inulin clearance values was used as the measured glomerular filtration rate. Estimated glomerular filtration rate based on serum creatinine and cystatin C levels was calculated using the Japanese estimated glomerular filtration rate equation, Chronic Kidney Disease Epidemiology Collaboration formula and new full age spectrum equation. Age-adjusted chronic kidney disease was defined as glomerular filtration rate <75 mL/min/1.73m2 for donors aged <40 years, <60 mL/min/1.73m2 for donors aged 40-65 years and <45 mL/min/1.73m2 for donors aged >65 years. The postoperative measured glomerular filtration rate <60 mL/min/1.73m2 and age-adjusted chronic kidney disease rate were 36.0% and 27.0%, respectively. In younger donors (aged <50 years), postoperative measured glomerular filtration rate <60 mL/min/1.73m2 and age-adjusted chronic kidney disease rates were 5.3% and 26.3%, respectively. In older donors (aged >70 years), postoperative measured glomerular filtration rate <6...Continue Reading

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Citations

Mar 13, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoichi KakutaKazunari Tanabe
Nov 27, 2019·Clinical and Experimental Nephrology·Osamu SomaChikara Ohyama

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