Assessment of resectability of pancreatic cancer with dynamic contrast-enhanced MR imaging: technique, surgical correlation and patient outcome

European Radiology
J A SpencerP J Robinson

Abstract

The aim of our work was to investigate the use of a dynamic contrast-enhanced MR (DCEMR) technique for staging apparently localised pancreatic cancer, and to determine the patterns of tumour and vascular enhancement with this technique. Thirty-five consecutive patients were examined. The MR findings were correlated with surgical findings in 13 patients and with clinical outcome in 22 patients. Breath-hold gradient-echo fast low angle shot (TR = 100, TE = 4, flip angle 80 degrees ) acquisitions were obtained at 10 and 40 s (right anterior coronal oblique plane) and at 90 s (axial plane) following intravenous gadolinium. Mean contrast-to-noise ratio was higher on the first than the second acquisition (p < 0. 001) and higher on the second acquisition than the third (p < 0.005). Tumour conspicuity was greatest and arterial anatomy was best demonstrated on the first acquisition and the portal venous anatomy on the second. Small tumours were isointense by the third acquisition. Maximal intensity projections were helpful. The MR findings correctly predicted the surgical findings in 11 of 13 cases (85 %) and the clinical course in the other 22 patients. The DCEMR imaging technique is valuable in the staging of patients with pancreatic ...Continue Reading

Citations

Mar 11, 2005·Abdominal Imaging·G KarmazanovskyA Kotchatkov
Feb 28, 2008·Topics in Magnetic Resonance Imaging : TMRI·Wolfgang SchimaClaus Koelblinger
Oct 9, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Isaac R Francis
Mar 1, 2002·European Radiology·Philip A Robinson
Sep 18, 2004·Seminars in Roentgenology·Silvana C FariaChusilp Charnsangavej
Nov 24, 2004·Gastrointestinal Endoscopy Clinics of North America·Andrew S Lowe, Clive L Kay
Jul 18, 2006·Journal of Computer Assisted Tomography·Sukru Mehmet ErturkTsutomu Araki

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