PMID: 9441717Jan 27, 1998Paper

Assessment of respiratory hypersensitivity in guinea pigs sensitized to toluene diisocyanate: improvements on analysis of respiratory response

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J Pauluhn

Abstract

Groups of guinea pigs of the Hartley strain were sensitized to toluene diisocyanate (TDI) by combined single intradermal injection and repeated inhalation exposure (3 h/day for 5 consecutive days) to 0, 3.8, 11, 26, 46, and 51 mg TDI/m3 air. One group of animals was sensitized by intradermal injection only. Sham-exposed and TDI-polyisocyanate resin-sensitized guinea pigs served as controls. Three weeks after the first encounter with the inducing agent, animals were challenged with the free TDI (approximately 0.5 mg/m3) and 1 week later with TDI-guinea pig serum albumin conjugate. Breathing patterns were analyzed by objective mathematical procedures taking into account the intensity and duration of the respiratory rate exceeding +/- 3 standard deviations of the individual prechallenge exposure period. In none of the animals challenged with TDI were conclusive immediate-onset respiratory responses identified. During the TDI conjugate challenge a characteristic increase in respiratory rate was observed in all groups sensitized with TDI. In each of the sham and TDI-resin control groups, 1 of 16 animals responded mildly to the conjugate challenge. With regard to analysis of the development of asthma-like dyspnea, the results obtaine...Continue Reading

Citations

Apr 5, 2003·Toxicology Letters·Josje H E Arts, C Frieke Kuper
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I KimberR J Dearman
Nov 21, 2007·Toxicology and Applied Pharmacology·Darrell R BoverhofMichael R Woolhiser
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Josje H E Arts, C Frieke Kuper
Apr 9, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jürgen Pauluhn, Ulrich Mohr
Jun 15, 2007·Alternatives to Laboratory Animals : ATLA·Ian KimberUNKNOWN European Centre for the Validation of Alternative Methods
May 12, 2006·Critical Reviews in Toxicology·Josje H E ArtsCees de Heer
Dec 24, 2002·Applied Occupational and Environmental Hygiene·Michael A Collins
May 17, 2002·Journal of Applied Toxicology : JAT·Edgar C KimmelKenneth R Still
Apr 28, 2005·International Archives of Allergy and Immunology·Takeshi NabeShigekatsu Kohno
May 15, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Edgar C KimmelRobert L Carpenter
Mar 29, 2002·Journal of Applied Toxicology : JAT·Jürgen PauluhnHans-Werner Vohr

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