PMID: 11899363Mar 20, 2002Paper

Assessment of response by breast helical computed tomography to neoadjuvant chemotherapy in large inflammatory breast cancer

Clinical Breast Cancer
Bernard MoysesSimon Schraub

Abstract

Breast helical computed tomography (CT) was evaluated for use in assessing response to neoadjuvant chemotherapy and residual tumor volume. Forty-three patients with large, inflammatory breast cancers (stage IIA, 12; IIB, 13; IIIA, 9; IIIB, 9), all histologically confirmed by core biopsy, were evaluated prior to and following neoadjuvant chemotherapy. The breast helical CT procedure involved patients in the prone position using single acquisition during quiet respiration following intravenous injection of nonionic contrast material. Helical CT results (3.2-mm slices and maximum intensity projections) were compared to clinical and mammographic evaluations, as well as to pathologic findings. All tumors were clearly visible by breast helical CT, showing important tumor enhancement. Helical CT evaluation of response to chemotherapy (using World Health Organization criteria) corresponded better with mammography (78%, Cohen's kappa statistic (kappa) = 0.65) than with clinical examination (53%, kappa = 0.30). Helical CT measurement of residual tumor volume after neoadjuvant chemotherapy and correlation with pathologic findings were globally satisfactory. The intraclass correlation coefficient was 0.69 (excellent for rounded opacities [...Continue Reading

Citations

Jan 5, 2007·Japanese Journal of Clinical Oncology·Chikako ShimizuYasuhiro Fujiwara
Apr 30, 2008·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Mitsuhiro Tozaki
Jul 31, 2008·Journal of Computer Assisted Tomography·Doo Kyoung KangHyunee Yim
May 4, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Laurence ChampionJean-Louis Alberini
Jan 21, 2006·AJR. American Journal of Roentgenology·Mitsuhiro TozakiKunihiko Fukuda
Feb 6, 2008·The Breast Journal·Salvatore MurgoLouisiane Lenaerts
Oct 14, 2005·Expert Review of Anticancer Therapy·Mark BeresfordAndreas Makris

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