Assessment of response to chemoradiation therapy in rectal cancer using MR volumetry based on diffusion-weighted data sets: a preliminary report.

La Radiologia medica
S F CarboneL Volterrani

Abstract

This study evaluated the feasibility of magnetic resonance (MR) volumetry using a diffusion-weighted data set (V(DWI)) and compared it with conventional T2-weighted volumetry (V(C)) in patients affected by rectal cancer treated with chemoradiation therapy (CHRT). Fourteen patients with a biopsy diagnosis of rectal cancer underwent MR examination before and after CHRT. T2-weighted images were used to extrapolate V(C). A diffusion-weighted (DW) sequence was acquired [spin-echo diffusion-weighted echo-planar imaging (SE-DW-EPI)] with a b-value of 800 s/mm(2) and volume (V(DWI)) was calculated by semiautomatic segmentation of tumour hyperintensity. Two radiologists independently assessed volumes and analysed data in order to establish interobserver agreement and compare and correlate volumes to tumour regression grade (TRG), as evaluable at pathological examination of the surgical specimen. Interobserver agreement was 0.977 [(95% confidence interval (CI) 0.954-0.989) and 0.956 (95% CI 0.905-0.980) for V(C) and V(DWI) and 0.964 (95% CI 0.896-0.988) and 0.271 (95% CI-0.267 to 0.686) between V(C) and V(DWI) before and after CHRT. The correlation between TRG and V(C) and V(DWI) was, respectively, rho = 0.597 (p<0.05) and r(2)=0.156 (p=...Continue Reading

References

Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·N A MayrW T Yuh
Jun 5, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M. J MorganM. J Solomon
Jan 27, 2005·AJR. American Journal of Roentgenology·Giacomo LuccichentiGabriel P Krestin
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Fabio Maria VecchioClaudio Coco
Mar 3, 2007·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Tomonori HosonumaKunihiko Fukuda
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·V Raman Muthusamy, Kenneth J Chang
Dec 12, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J SuárezC Zazpe
Dec 19, 2008·International Journal of Clinical Oncology·Toshiaki Watanabe
Feb 4, 2009·Neoplasia : an International Journal for Oncology Research·Anwar R PadhaniPeter L Choyke

❮ Previous
Next ❯

Citations

Mar 26, 2014·Nature Reviews. Gastroenterology & Hepatology·Regina G H Beets-Tan, Geerard L Beets
Feb 2, 2016·The British Journal of Radiology·Kirthi SathyakumarAnu Eapen
Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Miriam M van HeeswijkRegina G H Beets-Tan
Jan 17, 2016·NMR in Biomedicine·C J GalbánB D Ross
Nov 6, 2012·Radiologic Clinics of North America·Dow-Mu Koh, Aslam Sohaib
Sep 13, 2016·Diagnostic and Interventional Imaging·S Nougaret, P Rouanet
Jan 6, 2017·The British Journal of Radiology·Trang T PhamMichael B Barton
Aug 23, 2019·The British Journal of Surgery·S NougaretUNKNOWN GRECCAR Study Group
Sep 25, 2020·Clinics in Colon and Rectal Surgery·Deborah S Keller
May 1, 2019·Clinical Radiology·P J BrownD J Tolan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.