Assessment of Risk Factors and Outcomes of Severe Ehrlichiosis Infection.

JAMA Network Open
Kevin KuriakoseKaren C Bloch

Abstract

Ehrlichiosis cases in the US have increased more than 8-fold since 2000. Up to 57% of patients with ehrlichiosis require hospitalization and 11% develop a life-threatening complication; however, risk factors for serious disease are not well documented. To examine risk factors associated with severe ehrlichiosis. An analytic cross-sectional study of patients diagnosed with ehrlichiosis by polymerase chain reaction (PCR) between January 1, 2007, and December 31, 2017, was conducted in a single tertiary-care center in a region endemic for ehrlichiosis. Analysis was performed from February 27, 2018, to September 9, 2020. A total of 407 positive Ehrlichia PCR results were identified from 383 unique patients, with 155 unique patients meeting study criteria. Patients hospitalized at other institutions who had a positive Ehrlichia PCR performed as a reference test (n = 222) were excluded as no clinical data were available. Electronic medical record review was performed to collect demographic, clinical, laboratory, treatment, and outcomes data. Cases were excluded when there were insufficient clinical data to assess the severity of illness (n = 3) and when the clinical illness did not meet the case definition for ehrlichiosis (n = 3). D...Continue Reading

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Citations

Apr 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Wenqing ZhangYasuko Rikihisa

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Methods Mentioned

BETA
PCR
bronchoalveolar lavage

Software Mentioned

Excel
Stata

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