Abstract
Patients with essential thrombocythemia suffer from thrombotic complications that are the main source of mortality. Due to its complex pathogenesis, no existing single laboratory method is able to identify the patients at highest risk for developing thrombosis. Twenty patients with essential thrombocythemia at diagnosis, 15 healthy volunteers and 20 patients treated with hydroxyurea were compared with regard to certain rotation thromboelastometry parameters. Clotting time (CT), clot formation time (CFT), α-angle, and maximum clot firmness (MCF) were assessed by using the INTEM, EXTEM, FIBTEM, and NATEM tests. Patients with essential thrombocythemia at diagnosis demonstrated significantly higher mean platelet count and markedly lower mean red blood count than controls. CT and CFT readings were found to be markedly lower in essential thrombocythemia patients at diagnosis than in the control group according to the EXTEM test. Patients at diagnosis had markedly lower CT values (EXTEM, FIBTEM) than patients on hydroxyurea therapy. Alpha angle values were markedly higher in essential thrombocythemia patients at diagnosis than in controls, according to the EXTEM, FIBTEM and NATEM tests. MCF readings were significantly higher in essent...Continue Reading
References
May 15, 1991·Cancer·C RozmanM T Cortés
Apr 27, 1995·The New England Journal of Medicine·S CortelazzoT Barbui
Jul 20, 2000·Annals of Hematology·S BrodmannR C Skoda
Jun 22, 2001·Blood·P PiccardoniV Evangelista
Aug 9, 2001·British Journal of Anaesthesia·B M IselinD R Spahn
Jan 26, 2005·British Journal of Haematology·M A Elliott, A Tefferi
Mar 24, 2005·Clinical and Laboratory Haematology·R J Luddington
May 5, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Thomas LangMeret Lakner
Aug 31, 2007·Leukemia·G BarosiUNKNOWN International Working Group for Myelofibrosis Research and Treatment (IWG-MRT)
Jan 30, 2009·Pathophysiology of Haemostasis and Thrombosis·Marina Marchetti, Anna Falanga
Feb 20, 2009·Anesthesia and Analgesia·Thomas LangKenichi A Tanaka
Oct 4, 2012·Blood·Tiziano BarbuiAyalew Tefferi
Jan 26, 2013·Thrombosis Research·Michael NaglerWalter A Wuillemin
Jul 5, 2013·Blood·Tiziano BarbuiAnna Falanga
Oct 15, 2013·American Journal of Hematology·David Whiting, James A DiNardo
Jan 24, 2014·Thrombosis Research·Jacek TrelińskiKrzysztof Chojnowski
Jan 23, 2015·American Journal of Hematology·Ayalew Tefferi, Tiziano Barbui
Citations
Mar 15, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hui Y LimPrahlad Ho
Feb 15, 2018·Platelets·Mads Lamm LarsenErik Lerkevang Grove
Sep 29, 2021·Journal of Thrombosis and Thrombolysis·Vance G NielsenVictoria E Dotson