Assessment of salivary gland dysfunction after radioiodine therapy for thyroid carcinoma using non-contrast-enhanced CT: the significance of changes in volume and attenuation of the glands.

AJNR. American Journal of Neuroradiology
B NabaaT Aburano

Abstract

Although radiation induced damage to the salivary gland is a known complication of radioactive iodine ((131)I) therapy for thyroid carcinoma, prediction of the severity and reversibility of sialoadenitis is difficult. Our aim was to correlate the extent of salivary dysfunction assessed by salivary gland scintigraphy with changes in the volume and attenuation of salivary glands on nonenhanced CT in postoperative patients with thyroid cancer treated with RIT. Forty patients with thyroid carcinoma, 13 men (age range, 21-80 years) and 27 women (age range, 28-75 years) who underwent a total thyroidectomy and were treated with RIT were assessed retrospectively. On CT, the percentage of volume reduction and the difference in attenuation of the parotid and submandibular glands after RIT were determined and correlated with the extent of radiation-induced salivary dysfunction on scintigraphy. The salivary gland volume significantly decreased with an increase in the dysfunction grade on scintigraphy for both the parotid and submandibular glands (P < .001). The attenuation significantly increased with an increase in the dysfunction grade on scintigraphy for the parotid gland (P < .001), but not for the submandibular gland. The cutoff value...Continue Reading

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Citations

Jun 12, 2010·Clinical Oncology : a Journal of the Royal College of Radiologists·S E M Clarke
Jan 7, 2017·The Neuroradiology Journal·Ahmed Abdel Khalek Abdel Razek, Suresh Mukherji
Mar 9, 2018·Nuclear Medicine Communications·Mahdi HaghighatafsharTahereh Ghaedian
Apr 23, 2014·Nuclear Medicine Communications·Armaghan Fard-EsfahaniMohammad Eftekhari
May 7, 2020·Thyroid : Official Journal of the American Thyroid Association·Eleonora HorvathPaulina González
Jul 22, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Feride Kural RahatliNihal Uslu
Oct 17, 2014·Clinical Physiology and Functional Imaging·Pia AfzeliusKlaus Poulsen Bloch
Jun 19, 2021·Hormones : International Journal of Endocrinology and Metabolism·Marios AdramerinasKalliopi Pazaitou-Panayiotou

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